Results 141 to 150 of about 315,886 (312)

Matching trees for simplicial complexes and homotopy type of devoid complexes of graphs [PDF]

arXiv, 2015
We generalize some homotopy calculation techniques such as splittings and matching trees that are introduced for the computations in the case of the independence complexes of graphs to arbitrary simplicial complexes, and exemplify their efficiency on some simplicial complexes, the devoid complexes of graphs, which are simplicial complexes parametrized ...
arxiv  

Affinity‐Based Isolation and One‐Pot Analysis of Extracellular Vesicles from Biofluids Using Phase Separated Zwitterionic Coacervates

Advanced Science, EarlyView.
This study presents a novel method for affinity‐based isolation and analysis of extracellular vesicles from biofluids using phase‐separated zwitterionic coacervates functionalized with a membrane‐sensing peptide. This technology minimizes nonspecific binding, enabling high‐yield isolation and direct one‐pot biomarker profiling.
Francesca Torrini, Roberto Frigerio, Jonathan Garlipp, Philippe Lenzen, Karl Normak, Carolina Paganini, Marina Cretich, Alessandro Gori, Paolo Arosio   +8 more
wiley   +1 more source

From Invaginating Site to Deep Lesion: Spatial Transcriptomics Unravels Ectopic Endometrial Penetration Features in Adenomyosis

Advanced Science, EarlyView.
This work utilizes spatial transcriptomics to map the transcriptional landscape of adenomyosis with obvious invagination structure from the invaginating site to deep lesions. By integrating with single‐cell RNA sequencing, this study elucidates the molecular features of invagination, invasion, and fibrosis, and finds the major participants and vital ...
Boyu Li, Jia Qi, Yumeng Cao, Yijing Long, Zhe Wei, Wang‐Sheng Wang, Shuanggang Hu, Yuan Wang, Qinling Zhu, Xiao Hu, Zhe Sun, Jie Zhu, Taiyang Ye, Yejie Yao, Yiwen Meng, Xuejiao Bian, Xinyi Dong, Hengyu Guan, Yunfei Huang, Yun Sun   +19 more
wiley   +1 more source

The phospholipid flippase ATP8B1 is required for lysosomal fusion in macrophages

Cell Biochemistry and Function, Volume 40, Issue 8, Page 914-925, December 2022., 2022
Abstract ATP8B1 is a phospholipid flippase and member of the type 4 subfamily of P‐type ATPases (P4‐ATPase) subfamily. P4‐ATPases catalyze the translocation of phospholipids across biological membranes, ensuring proper membrane asymmetry, which is crucial for membrane protein targeting and activity, vesicle biogenesis, and barrier function.
Valentina E. Gómez‐Mellado, Kam S. Ho‐Mok, Vincent A. van der Mark, Nicole N. van der Wel, Anita E. Grootemaat, Arthur J. Verhoeven, Ronald P. J. Oude Elferink, Coen C. Paulusma   +7 more
wiley   +1 more source

Complexes of trees and nested set complexes [PDF]

arXiv, 2004
We exhibit an identity of abstract simplicial complexes between the well-studied complex of trees and the reduced minimal nested set complex of the partition lattice. We conclude that the order complex of the partition lattice can be obtained from the complex of trees by a sequence of stellar subdivisions.
arxiv  

Exosomes Derived from Stem Cells from the Apical Papilla Promote Dentine-Pulp Complex Regeneration by Inducing Specific Dentinogenesis [PDF]

, 2020
Xueying Zhuang, Lingli Ji, Huan Jiang, Yao Liu, Xuemei Liu, Jing Bi, Wei‐Dong Zhao, Zhenjiang Ding, Xu Chen   +8 more
openalex   +1 more source

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

Advanced Science, EarlyView.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li, Shuhan Jin, Danke Wang, Ying Wu, Xiaoyu Tang, Yufan Liu, Tiange Yao, Shoufa Han, Lin Sun, Yuetong Wang, Steven X. Hou   +10 more
wiley   +1 more source

Fabrication and Functionalisation of Nanocarbon‐Based Field‐Effect Transistor Biosensors

ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
Next‐generation diagnostics: Nanocarbon‐based field effect transistors (NC‐FETs) use incoming target analytes to impart a gating effect on conductance. Here, we review the operational mechanisms behind NC‐FETs, the fabrication and functionalisation of NC‐FETs with receptor biomolecules and downstream biosensing applications.
Chang‐Seuk Lee, Rebecca E. A. Gwyther, Mark Freeley, Dafydd Jones, Matteo Palma   +4 more
wiley   +1 more source

Exosomes: Membrane-associated proteins, challenges and perspectives

Biochemistry and Biophysics Reports
Membrane proteins determine the precise function of each membrane and, therefore, the function of each cell type. These proteins play essential roles in cell physiology, participating in the maintenance of the cell metabolism, its homeostasis or ...
Nuria Palomar-Alonso, Mijung Lee, Manho Kim   +2 more
doaj  

Pressure-dependent adhesion between solid-supported PC-lipid bilayers and vesicles under electric fields [PDF]

arXiv
Fusion of lipid bilayers in membranes is important in processes from vesicle-cell interactions (as in drug delivery) to exosome-cell signaling, while transient transmembrane electric fields are known to occur spontaneously. Two contacting phosphatidylcholine (PC) lipid membranes are known to fuse into one under external electric fields, suggesting that
arxiv