Results 151 to 160 of about 62,378 (298)
TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex
, 2002 Nicolas Blanchard +6 more
openalex +1 more source
Advanced Science, EarlyView.The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang +11 more
wiley +1 more source
RNA 3′end tailing safeguards cells against products of pervasive transcription termination
Nature CommunicationsPremature transcription termination yields a wealth of unadenylated (pA−) RNA. Although this can be targeted for degradation by the Nuclear EXosome Targeting (NEXT) complex, possible backup pathways remain poorly understood.
Guifen Wu +3 more
doaj +1 more source
A complex prediction: three‐dimensional model of the yeast exosome
, 2002 Patrick Aloy +7 more
openalex +2 more sources
Engineered Foxp1high Exosomes Ameliorates Systemic Lupus Erythematosus
Advanced Science, EarlyView.This study presents a dual‐engineering strategy combining mesenchymal stem cell aggregation and Foxp1 overexpression to generate Foxp1high aggregation exosomes with enhanced immunomodulatory properties. These engineered exosomes exhibit immune organ targeting and superior efficacy in systemic lupus erythematosus treatment by promoting Treg ...
Luhan Niu +9 more
wiley +1 more source
Advanced Science, EarlyView.This study designs an injectable porous hydrogel (HMs/MBs/ADSCs) integrating hollow microspheres for sustained BMP‐2 release to enhance adipose‐derived stem cells' paracrine effect. It accelerates tendon‐bone healing in rat rotator cuff injuries via spatiotemporal regulation: early AMPK‐mediated mitochondrial protection and late TGF‐β/Smad2/3‐driven ...
Meijuan Yuan +11 more
wiley +1 more source
Advanced Science, EarlyView.Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen +12 more
wiley +1 more source