Results 151 to 160 of about 6,729,673 (335)

The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism [PDF]

, 2022
Alexander Kögel, Achim Keidel, Fabien Bonneau, Ingmar B. Schäfer, Elena Conti   +4 more
openalex   +1 more source

Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants

Advanced Science, EarlyView.
In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao, Yanbin Li, Shengqi Zhang, Yilin He, Zhiqi Liu, Juan Wang, Jingmin Hua, Jinyu Chen, Junru Zhong, Huan Zhong, Yiji Xia, Yong Cui, Liwen Jiang   +12 more
wiley   +1 more source

The Exosome Complex in Health and Disease: A Multifaceted Regulator of RNA Homeostasis

Experimed
The RNA exosome complex is a multi-subunit ribonuclease complex that participates in RNA degradation, processing, and quality control. In recent years, mutations and dysregulation in the subunits of this complex, which play significant roles in RNA ...
Esra Nur Demirtaş, Selcuk Sozer Tokdemir   +1 more
doaj   +1 more source

KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells

BMC Cell Biology, 2009
Background Parathyroid hormone (PTH) gene expression is regulated post-transcriptionally through the binding of the trans-acting proteins AU rich binding factor 1 (AUF1), Upstream of N-ras (Unr) and KH-type splicing regulatory protein (KSRP) to an AU ...
Schoenberg Daniel R, Gherzi Roberto, Briata Paola, Bell Osnat, Peng Yong, Nechama Morris, Naveh-Many Tally   +6 more
doaj   +1 more source

Stem cell-derived exosomes for dentin-pulp complex regeneration: a mini-review

, 2023
Dina A. Hammouda, Alaa Mansour, Mahmoud Saeed, Ahmed R. Zaher, Mohammed E. Grawish   +4 more
openalex   +1 more source

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

Advanced Science, EarlyView.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
wiley   +1 more source

RNA substrate length as an indicator of exosome interactions in vivo [version 1; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2017
Background: The exosome complex plays key roles in RNA processing and degradation in Eukaryotes and Archaea. Outstanding structural studies identified multiple pathways for RNA substrates into the exosome in vitro, but identifying the pathway followed by
Clémentine Delan-Forino, Claudia Schneider, David Tollervey   +2 more
doaj   +1 more source

Interplay of the RNA Exosome Complex and RNA-Binding Protein Ssd1 in Maintaining Cell Wall Stability in Yeast. [PDF]

Microbiol Spectr, 2021
Novačić A, Šupljika N, Bekavac N, Žunar B, Stuparević I.   +4 more
europepmc   +1 more source

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis [PDF]

Yongjin Lee, Adriano Biasini, Cindy Tipping, Seong Hyeon Hong, Phillip D. Zamore   +4 more
openalex   +2 more sources