Results 161 to 170 of about 315,886 (312)

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

The RNA exosome nuclease complex regulates human embryonic stem cell differentiation [PDF]

, 2019
Cédric Belair, Soyeong Sim, Kun‐Yong Kim, Yoshiaki Tanaka, In‐Hyun Park, Sandra L. Wolin   +5 more
openalex   +1 more source

Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway

Advanced Science, EarlyView.
Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie, Shang‐Hui Ye, Yu‐Ting Yue, Bao‐Hong Shi, Jing‐Ping Xu, Lian‐Jie Li, Zheng‐Biao Zou, Matthew B. Greenblatt, Na Li, Xian‐Wen Yang, Ren Xu   +10 more
wiley   +1 more source

TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex

, 2002
Nicolas Blanchard, Danielle Lankar, Florence Faure, Armelle Régnault, Céline Dumont, Graça Raposo, Claire Hivroz   +6 more
openalex   +1 more source

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

Advanced Science, EarlyView.
Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen, Dongwei Liu, Lei Lei, Ting Liu, Shaokang Pan, Hui Wang, Yong Liu, Yingjin Qiao, Zhangsuo Liu, Qi Feng   +9 more
wiley   +1 more source

RNA 3′end tailing safeguards cells against products of pervasive transcription termination

Nature Communications
Premature transcription termination yields a wealth of unadenylated (pA−) RNA. Although this can be targeted for degradation by the Nuclear EXosome Targeting (NEXT) complex, possible backup pathways remain poorly understood.
Guifen Wu, Jérôme O. Rouvière, Manfred Schmid, Torben Heick Jensen   +3 more
doaj   +1 more source

Lipid Droplets Metabolism Mediated by ANXA7‐PPARγ Signaling Axis Regulates Spinal Cord Injury Repair in Mice

Advanced Science, EarlyView.
This work proposes a new mechanism for the regulation of LDs metabolism by ANXA7/PPARγ. ANXA7 can interact with PPARγ to promote its stability. ANXA7 activation promotes PPARγ nuclear translocation, thus promoting LDs formation and interaction with mitochondria by promoting PLIN5 expression.
Lu Chen, Haoran Liu, Linlin Jiang, Zihang Wang, Yong Chang, Na Li, Shiqing Feng   +6 more
wiley   +1 more source

Rapid isolation and quantification of extracellular vesicles from suspension‐adapted human embryonic kidney cells using capillary‐channeled polymer fiber spin‐down tips

ELECTROPHORESIS, Volume 44, Issue 1-2, Page 190-202, January 2023., 2023
Abstract Exosomes, a subset of extracellular vesicles (EVs, 30–200‐nm diameter), serve as biomolecular snapshots of their cell of origin and vehicles for intercellular communication, playing roles in biological processes, including homeostasis maintenance and immune modulation.
Kaylan K. Jackson, R. Kenneth Marcus
wiley   +1 more source

Exosome-based therapies for inflammatory disorders: a review of recent advances

Stem Cell Research & Therapy
Exosomes, small extracellular vesicles secreted by cells, have emerged as focal mediators in intercellular communication and therapeutic interventions across diverse biomedical fields.
Mavra Saleem, Khawar Ali Shahzad, Munazzah Marryum, Shekhar Singh, Quan Zhou, Siting Du, Shuanghu Wang, Chuxiao Shao, Imran Ibrahim Shaikh   +8 more
doaj   +1 more source

Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection1

, 2003
Hélène Pêche, Michèle Heslan, Claire Usal, Sebastián Amigorena, María Cristina Cuturi   +4 more
openalex   +1 more source