CryoEM structure of yeast cytoplasmic exosome complex. [PDF]
Cell Res, 2016 The eukaryotic multi-subunit RNA exosome complex plays crucial roles in 3'-to-5' RNA processing and decay. Rrp6 and Ski7 are the major cofactors for the nuclear and cytoplasmic exosomes, respectively. In the cytoplasm, Ski7 helps the exosome to target mRNAs for degradation and turnover via a through-core pathway.
Liu JJ +14 more
europepmc +5 more sources
Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex. [PDF]
Mol Cell, 2016 The RNA exosome complex associates with nuclear and cytoplasmic cofactors to mediate the decay, surveillance, or processing of a wide variety of transcripts. In the cytoplasm, the conserved core of the exosome (Exo10) functions together with the conserved Ski complex. The interaction of S.
Kowalinski E +6 more
europepmc +5 more sources
The exosome complex establishes a barricade to erythroid maturation. [PDF]
Blood, 2014 Key Points Exosome complex components are endogenous suppressors of erythroid cell maturation. GATA-1 and Foxo3 transcriptionally repress exosome complex components, thus abrogating the erythroid maturation blockade.
McIver SC +11 more
europepmc +4 more sources
Autoantibodies directed to novel components of the PM/Scl complex, the human exosome [PDF]
Arthritis Research & Therapy, 2001 The autoantigenic polymyositis/scleroderma (PM/Scl) complex was recently shown to be the human homologue of the yeast exosome, which is an RNA-processing complex. Our aim was to assess whether, in addition to targeting the known autoantigens PM/Scl-100 and PM/Scl-75, autoantibodies also target recently identified components of the PM/Scl complex.
Rick Brouwer +10 more
openalex +6 more sources
The Human Nuclear Exosome Targeting Complex Is Loaded onto Newly Synthesized RNA to Direct Early Ribonucleolysis [PDF]
Cell Reports, 2015 The RNA exosome complex constitutes the major nuclear eukaryotic 3′-5′ exonuclease. Outside of nucleoli, the human nucleoplasmic exosome is directed to some of its substrates by the nuclear exosome targeting (NEXT) complex.
Michal Lubas +5 more
doaj +2 more sources
Exosome and
Journal of Cellular and Molecular Medicine, 2023 AbstractThis short communication will enlighten the readers about the exosome and the epithelial‐mesenchymal transition (EMT) related to several complicated events. It also highlighted the therapeutic potential of exosomes against EMT. Exosome toxicology, exosome heterogeneity, and a single exosome profiling approach are also covered in this article ...
Rajib Dhar +5 more
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RNA Degradation by the Exosome Is Promoted by a Nuclear Polyadenylation Complex [PDF]
Cell, 2005 The exosome complex of 3'-5' exonucleases participates in RNA maturation and quality control and can rapidly degrade RNA-protein complexes in vivo. However, the purified exosome showed weak in vitro activity, indicating that rapid RNA degradation requires activating cofactors.
John LaCava +6 more
openalex +8 more sources
The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma [PDF]
Arthritis Research & Therapy, 2000 The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75.
Rick Brouwer +2 more
openalex +6 more sources
The Sm complex is required for the processing of non-coding RNAs by the exosome. [PDF]
PLoS ONE, 2013 A key question in the field of RNA regulation is how some exosome substrates, such as spliceosomal snRNAs and telomerase RNA, evade degradation and are processed into stable, functional RNA molecules.
Sarah Coy +3 more
doaj +5 more sources
A budding yeast model for human disease mutations in the EXOSC2 cap subunit of the RNA exosome complex. [PDF]
RNA, 2021 Sterrett MC +13 more
europepmc +3 more sources