Results 11 to 20 of about 6,729,673 (335)
Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome [PDF]
Molecular Cell, 2022 In mammalian cells, spurious transcription results in a vast repertoire of unproductive non-coding RNAs, whose deleterious accumulation is prevented by rapid decay. The nuclear exosome targeting (NEXT) complex plays a central role in directing non-functional transcripts to exosome-mediated degradation, but the structural and molecular mechanisms remain
P. Gerlach +7 more
semanticscholar +6 more sources
CryoEM structure of yeast cytoplasmic exosome complex. [PDF]
Cell Res, 2016 The eukaryotic multi-subunit RNA exosome complex plays crucial roles in 3'-to-5' RNA processing and decay. Rrp6 and Ski7 are the major cofactors for the nuclear and cytoplasmic exosomes, respectively. In the cytoplasm, Ski7 helps the exosome to target mRNAs for degradation and turnover via a through-core pathway.
Liu JJ +14 more
europepmc +5 more sources
Exosome complex and erythropoiesis. [PDF]
Blood, 2014 In this issue of Blood , McIver et al demonstrate that components of the exosome complex are endogenous suppressors of erythroid maturation, revealing a new and novel regulatory mechanism for erythroid development.[1][1] ![Figure][2] Schematic model of GATA1/Foxo3-exosome complex network.
X. An
semanticscholar +4 more sources
Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex. [PDF]
Mol Cell, 2016 The RNA exosome complex associates with nuclear and cytoplasmic cofactors to mediate the decay, surveillance, or processing of a wide variety of transcripts. In the cytoplasm, the conserved core of the exosome (Exo10) functions together with the conserved Ski complex. The interaction of S.
Kowalinski E +6 more
europepmc +5 more sources
Exosome complex genes mediate RNA degradation and predict survival in mantle cell lymphoma. [PDF]
Oncol Lett, 2019 Exosome complex (EXOSC) genes, which encode a multi-protein intracellular complex, mediate the degradation of various types of RNA molecules. EXOSCs, also known as polymyositis/scleroderma complexes, exist in eukaryotic cells and archaea, and primarily ...
Zhang W +11 more
europepmc +2 more sources
Exosome Complex Exonuclease RRP44 [PDF]
Definitions, 2020 Exosome complex exonuclease RRP44 (958 aa, ~109 kDa) is encoded by the human DIS3 gene. This protein is involved in the mediation of rRNA processing.
semanticscholar +2 more sources
RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells [PDF]
Stem Cell Reports, 2017 The RNA exosome complex targets AU-rich element (ARE)-containing mRNAs in eukaryotic cells. We identified a transcription factor, ZSCAN10, which binds to the promoters of multiple RNA exosome complex subunits in pluripotent stem cells to maintain subunit
Maria Skamagki +10 more
doaj +2 more sources
EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks [PDF]
Nature Communications, 2019 The exosome is a ribonucleolytic complex that plays part in RNA processing and degradation. Here, the authors reveal an RNA clearance event in homologous recombination and show the function of EXOSC10, a component of the exosome, in the homeostasis of ...
Judit Domingo-Prim +7 more
doaj +3 more sources
The Rrp4-exosome complex recruits and channels substrate RNA by a unique mechanism. [PDF]
Nat Chem Biol, 2017 The exosome is a large molecular machine that is involved in RNA degradation and processing. Here, we address how the trimeric Rrp4 cap enhances the activity of the archaeal enzyme complex.
Cvetkovic MA +4 more
europepmc +2 more sources
The exosome complex establishes a barricade to erythroid maturation.
Blood, 2014 Key Points Exosome complex components are endogenous suppressors of erythroid cell maturation. GATA-1 and Foxo3 transcriptionally repress exosome complex components, thus abrogating the erythroid maturation blockade.
McIver SC +11 more
europepmc +5 more sources