Results 191 to 200 of about 6,729,673 (335)

4D structural biology-quantitative dynamics in the eukaryotic RNA exosome complex. [PDF]

Nat Commun
Liebau J, Lazzaretti D, Fürtges T, Bichler A, Pilsl M, Rudack T, Sprangers R.   +6 more
europepmc   +2 more sources

ECERIFERUM7 subunit of the exosome, SUPERKILLER complex and small RNA species regulate cuticular wax biosynthesis in Arabidopsis thaliana stems

, 2016
Lifang Zhao
openalex   +1 more source

Co-surveillance of ribosomal RNA by the exosome complex and nucleolar RNAi in C. elegans [PDF]

, 2020
Shimiao Liao, Xiangyang Chen, Ting Xu, Qile Jin, Zongxiu Xu, Demin Xu, Xufei Zhou, Chengming Zhu, Shouhong Guang, Xuezhu Feng   +9 more
openalex   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Exosome-based liquid biopsy for rare and complex diseases

International Journal of Surgery
Exosomes, a class of nano-sized extracellular vesicles secreted by virtually all cell types, have emerged as powerful mediators of intercellular communication and promising tools for biomarker discovery. Rich in proteins, lipids, nucleic acids, and metabolites that reflect the physiological and pathological status of their cells of origin, exosomes ...
Jiale Li, Jun Peng, Haijun Guo, Wei Zheng, Rui Chen, Changfeng Miao, Jiachong Wang, Zigui Chen, Chunhai Tang   +8 more
openaire   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Exosome-based therapies for inflammatory disorders: a review of recent advances

Stem Cell Research & Therapy
Exosomes, small extracellular vesicles secreted by cells, have emerged as focal mediators in intercellular communication and therapeutic interventions across diverse biomedical fields.
Mavra Saleem, Khawar Ali Shahzad, Munazzah Marryum, Shekhar Singh, Quan Zhou, Siting Du, Shuanghu Wang, Chuxiao Shao, Imran Ibrahim Shaikh   +8 more
doaj   +1 more source

TRAMP Complex Enhances RNA Degradation by the Nuclear Exosome Component Rrp6 [PDF]

, 2009
Kevin P. Callahan, J. Scott Butler
openalex   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

RNA 3′end tailing safeguards cells against products of pervasive transcription termination

Nature Communications
Premature transcription termination yields a wealth of unadenylated (pA−) RNA. Although this can be targeted for degradation by the Nuclear EXosome Targeting (NEXT) complex, possible backup pathways remain poorly understood.
Guifen Wu, Jérôme O. Rouvière, Manfred Schmid, Torben Heick Jensen   +3 more
doaj   +1 more source