Results 201 to 210 of about 62,378 (298)

The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome [PDF]

, 2015
Yang Zhou, Jianguo Zhu, Géza Schermann, Corina Ohle, Katja Bendrin, Rie Sugioka-Sugiyama, Tomoyasu Sugiyama, Tamás Fischer   +7 more
openalex   +1 more source

An MOF‐Enhanced Anti‐Fouling Immunoprobe Platform for Efficient Direct Screening of Pancreatic Cancer

Advanced Science, EarlyView.
This work introduces an electrochemical sensing method that employs an innovative platform based on metal‐organic framework (MOF) for detecting biomarkers. The platform integrates an antifouling surface, oriented antibody immobilization, and an enhanced electron transfer layer.
Wenjuan Yang, Shujuan Mao, Hao Zhu, Handong Yao, Wei Jin, Lingyan Feng, Xinghua Gao, Xuefeng Wang, Wei Chen, Min Tu, Yuan Zhang   +10 more
wiley   +1 more source

Molecular Mechanism of Processive 3' to 5' RNA Translocation in the Active Subunit of the RNA Exosome Complex. [PDF]

J Am Chem Soc, 2016
Vuković L, Chipot C, Makino DL, Conti E, Schulten K.   +4 more
europepmc   +1 more source

In Situ Programming of the Tumor Microenvironment to Alleviate Immunosuppression for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
cmExoaCD11b induced the repolarization of immunosuppressive M2 macrophages into pro‐inflammatory M1 phenotype, thereby promoting the proliferation and activation of CD8+ T cells and reversing the immunosuppressive state of the tumor microenvironment.
Man Sun, Huan Zhang, Yarui Ma, Simiao Wang, Jiayi Chen, Yaxin Cui, Yun Zhang, Siyuan Hu, Dan Zhou, Pengchen Zhang, Yahui Liu, Betty Y.S. Kim, Wen Jiang, Xiaobing Wang, Zhaogang Yang   +14 more
wiley   +1 more source

Pancreatic Cancer‐Derived Extracellular Vesicles Enriched with miR‐223‐5p Promote Skeletal Muscle Wasting Associated with Cachexia

Advanced Science, EarlyView.
EVs and EV‐microRNAs (miRNAs) mediate PDAC‐skeletal muscle communication. miR‐223‐5p reduces METTL14 transcription by targeting MAFA, which subsequently decreases m6A methylation in skeletal muscles, ultimately leading to muscle wasting. This study highlights the absorption of miRNA in PDAC‐derived EVs by skeletal muscles and reveals a previously ...
Kangjing Xu, Rongxi Shen, Li Zhang, Xuejin Gao, Xinbo Wang, Changhua Zhang, Xi Chen, Xinying Wang   +7 more
wiley   +1 more source

RNA Exosome Complex Regulates Stability of the Hepatitis B Virus X-mRNA Transcript in a Non-stop-mediated (NSD) RNA Quality Control Mechanism [PDF]

, 2016
Hussein H. Aly, Junya Suzuki, Koichi Watashi, Kazuaki Chayama, S. Hoshino, Makoto Hijikata, Takanobu Kato, Takaji Wakita   +7 more
openalex   +1 more source

Autophagy‐Mediated Suppression of Tumor Growth by Food‐Grade Lipid Nanoparticles in Mice

Advanced Science, EarlyView.
This work reveals a novel extracellular nanoparticle transport and metabolic pathway. Following cellular uptake, Food‐grade lipid nanoparticles (FLNs) selectively fuse with lipid droplets (LDs) rather than lysosomes, driving LDs accumulation. This process activates autophagy through the AMPK‐mTOR‐ULK1 signaling axis, facilitating tumor progression ...
Chenglu Peng, Bing Jiang, Wei Lu, Przemyslaw Zalewski, Jun He, Xiaoyang Li, Yiping Cao, Yiguo Zhao, Cuixia Sun, Katsuyoshi Nishinari, Yapeng Fang   +10 more
wiley   +1 more source

Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex.

Mol Cell, 2016
Kowalinski E, Kögel A, Ebert J, Reichelt P, Stegmann E, Habermann B, Conti E.   +6 more
europepmc   +1 more source

The yeast exosome and human PM-Scl are related complexes of 3' right-arrow 5' exonucleases

, 1999
Christine Allmang, E Petfalski, Alexander Podtelejnikov, Matthias Mann, David Tollervey, Paul Mitchell   +5 more
openalex   +1 more source

Human iPSCs Derived MSCs‐Secreted Exosomes Modulate Senescent Nucleus Pulposus Cells Induced Macrophage Polarization via Metabolic Reprogramming to Mitigate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Senescent nucleus pulposus cells drive inflammatory M1 macrophage polarization, exacerbating intervertebral disc degeneration (IDD). Conversely, M1 macrophages accelerate NP cell senescence, creating a vicious cycle. iPSCs‐derived mesenchymal stem cell (iMSCs) exosomes break this loop by delivering miR‐100‐5p to suppress mTORC1/glycolysis in ...
Qian Xiang, Jiawen Zhan, Shuo Tian, Yongzhao Zhao, Zhenquan Wu, Jialiang Lin, Longting Chen, Longjie Wang, Shuai Jiang, Zhuoran Sun, Weishi Li   +10 more
wiley   +1 more source