Results 231 to 240 of about 61,126 (326)

Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells

Advanced Science, EarlyView.
Using microfluidic models of capillary networks, this study discovered that fluid shear stresses on circulating tumor cells transiting through capillary‐sized bifurcations shed a novel class of shear‐dependent large extracellular vesicle, “shearosomes”, whose proteome comprises of over 3000 distinct proteins.
Angelos Vrynas, Salime Bazban‐Shotorbani, Sara Arfan, Karishma Satia, Brian Cunningham, Gauhar Sagindykova, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Teige Matthews‐Palmer, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au   +16 more
wiley   +1 more source

The yeast exosome and human PM-Scl are related complexes of 3' right-arrow 5' exonucleases

, 1999
Christine Allmang, E Petfalski, Alexander Podtelejnikov, Matthias Mann, David Tollervey, Paul Mitchell   +5 more
openalex   +1 more source

Enhancing Chemotherapy‐Related Immune Responses via Bioorthogonal Metabolic Engineering‐Driven Tumor Exosomes Elimination

Advanced Science, EarlyView.
In this work, a novel strategy named bioorthogonal reaction‐driven exosome elimination (Biordee) strategy was developed to inhibit chemotherapy‐associated breast cancer metastasis and enhance the immune response. Biordee possessed the capacity of in‐situ editing tumor‐derived exosomes (TExo) with IgG Fc and promoted macrophage phagocytosis of ...
Wentao Zhang, Tianyi Yang, Tian Jin, Tianyi Zhu, Fang Hao, Miao Fan, Yanrong Zhang   +6 more
wiley   +1 more source

Molecular Mechanism of Processive 3' to 5' RNA Translocation in the Active Subunit of the RNA Exosome Complex. [PDF]

J Am Chem Soc, 2016
Vuković L, Chipot C, Makino DL, Conti E, Schulten K.   +4 more
europepmc   +1 more source

Exosome Enveloped by Nano Lipid Particle a New Model for Signal Transducer and Activator of Transcription 3 Silencer Ribonucleic Acid Delivery System to a Glioblastoma Mice Model. [PDF]

Cancers (Basel)
Monfaredan A, Şen S, Hosseininasab A, Taştekin D, Fazli G, Bozbey HU, Yousefi N, Hocaoğlu M, Öncül MO, Özen RS.   +9 more
europepmc   +1 more source

A Pump‐Free, Hydraulic‐Amplification Oscillatory Microfluidic Device for Continuous Particle and Cell Manipulation

Advanced Science, EarlyView.
This study demonstrates a pump‐free, hydraulic‐amplification oscillatory microfluidic device, which generates oscillatory flows by deforming flexible microchannels through reciprocating finger pressing. The mechanism of elasto‐inertial focusing in the oscillatory flows is revealed, and early detection of drug‐treated platelet aggregates and rapid cell ...
Yong Liu, Mingyi Liang, Shanshan Xu, Sheng Yan   +3 more
wiley   +1 more source

AID recruits the RNA exosome to degrade HIV ‐1 nascent transcripts through interaction with the Tat‐P‐ TEF b‐ TAR RNP complex [PDF]

, 2017
Ruixuan Wang, Xiaowei Zhang, Haibo Ding, Ying Qiao, Xiaoxu Han, Wenqing Geng, Gefei Guan, Hualu Cui, Bin Zhao, Yuntao Wu, Guoxin Liang, Hong Shang   +11 more
openalex   +1 more source

Isolation methods of exosomes derived from dental stem cells. [PDF]

Int J Oral Sci
Ahmad P, Estrin N, Farshidfar N, Zhang Y, Miron RJ.   +4 more
europepmc   +1 more source

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

Advanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng, Qin Lin, Yizhuo Sun, Yilei Meng, Sangyu Hu, Huaming Cao, Fang Lin, Yuping Zhu, Luying Peng, Li Li   +9 more
wiley   +1 more source

Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

Aggregate, EarlyView.
This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun‐Xia Zhao, Yun Liu   +5 more
wiley   +1 more source