TGF-β suppression of HBV RNA through AID-dependent recruitment of an RNA exosome complex.
PLoS Pathogens, 2015 Transforming growth factor (TGF)-β inhibits hepatitis B virus (HBV) replication although the intracellular effectors involved are not determined.
Guoxin Liang +10 more
doaj +3 more sources
Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex [PDF]
Molecular Cell, 2011 The RNA exosome is a conserved degradation machinery, which obtains full activity only when associated with cofactors. The most prominent activator of the yeast nuclear exosome is the RNA helicase Mtr4p, acting in the context of the Trf4p/Air2p/Mtr4p polyadenylation (TRAMP) complex. The existence of a similar activator(s) in humans remains elusive.
Michał Lubas +8 more
openalex +7 more sources
CRABP1-complexes in exosome secretion
Cell Communication and SignalingBackground Cellular retinoic acid binding protein 1 (CRABP1) mediates rapid, non-canonical activity of retinoic acid (RA) by forming signalosomes via protein-protein interactions.
Jennifer Nhieu +4 more
doaj +3 more sources
Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA. [PDF]
Nature, 2014 The eukaryotic RNA exosome processes and degrades RNA by directing substrates to the distributive or processive 3' to 5' exoribonuclease activities of Rrp6 or Rrp44, respectively. The non-catalytic nine-subunit exosome core (Exo9) features a prominent central channel. Although RNA can pass through the channel to engage Rrp44, it is not clear how RNA is
Wasmuth EV, Januszyk K, Lima CD.
europepmc +5 more sources
The Rrp4-exosome complex recruits and channels substrate RNA by a unique mechanism. [PDF]
Nat Chem Biol, 2017 Cvetkovic MA +4 more
europepmc +3 more sources
Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome [PDF]
Molecular Cell, 2022 In mammalian cells, spurious transcription results in a vast repertoire of unproductive non-coding RNAs, whose deleterious accumulation is prevented by rapid decay. The nuclear exosome targeting (NEXT) complex plays a central role in directing non-functional transcripts to exosome-mediated degradation, but the structural and molecular mechanisms remain
Gerlach, Piotr +7 more
openaire +2 more sources
Exosome Release by Glucose Deprivation Is Important for the Viability of TSC-Null Cells
Cells, 2022 The control of exosome release is associated with numerous physiological and pathological activities, and that release is often indicative of health, disease, and environmental nutrient stress.
Ji-Hyun Bae, Jong Hyun Kim
doaj +1 more source
Ferroptosis and Cancer: Complex Relationship and Potential Application of Exosomes [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cell death induction has become popular as a novel cancer treatment. Ferroptosis, a newly discovered form of cell death, features regulated, iron-dependent accumulation of lipid hydroperoxides. Since this word “ferroptosis” was coined, numerous studies have examined the complex relationship between ferroptosis and cancer.
Shuang Wu +4 more
openaire +4 more sources
Development of Antibody–Oligonucleotide Complexes for Targeting Exosomal MicroRNA [PDF]
Pharmaceutics, 2020 MicroRNAs in exosomes (exosomal miRNAs) are considered as significant targets for cancer therapy. Anti-miR oligonucleotides are often used for the functional inhibition of miRNAs; however, there are no studies regarding the regulation of exosomal miRNA functions.
Eishi Ashihara +10 more
openaire +4 more sources
Nab3 facilitates the function of the TRAMP complex in RNA processing via recruitment of Rrp6 independent of Nrd1. [PDF]
PLoS Genetics, 2015 Non-coding RNAs (ncRNAs) play critical roles in gene regulation. In eukaryotic cells, ncRNAs are processed and/or degraded by the nuclear exosome, a ribonuclease complex containing catalytic subunits Dis3 and Rrp6.
Milo B Fasken +2 more
doaj +1 more source