PLoS Genetics, 2020 The RNA exosome is an evolutionarily-conserved ribonuclease complex critically important for precise processing and/or complete degradation of a variety of cellular RNAs.
Derrick J Morton +16 more
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Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma [PDF]
, 2016 BACKGROUND: Growing evidence is showing that metastatic cell populations are able to transfer their characteristics to less malignant cells. Exosomes (EXOs) are membrane vesicles of endocytic origin able to convey their cargo of mRNAs, microRNAs (miRs),
Bellenghi, Maria +9 more
core +5 more sources
The 3' to 5' exoribonuclease DIS3: from structure and mechanisms to biological functions and role in human disease [PDF]
, 2015 DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3’ to 5’ degradation and processing of both nuclear and cytoplasmic RNA species.
Carazo-Salas +7 more
core +2 more sources
A targeted siRNA‐loaded PDL1‐exosome and functional evaluation against lung cancer
Thoracic Cancer, 2022 Background As an endocytic nanosicle involved in intercellular communication, an exosome can efficiently deliver drugs from one cell to another and deliver therapeutic short interfering RNA (siRNA) to target cells.
Xianbin Lin +6 more
doaj +1 more source
The 5' → 3' exoribonuclease XRN1/Pacman and its functions in cellular processes and development [PDF]
, 2012 XRN1 is a 5' → 3' processive exoribonuclease that degrades mRNAs after they have been decapped. It is highly conserved in all eukaryotes, including homologs in Drosophila melanogaster (Pacman), Caenorhabditis elegans (XRN1), and Saccharomyces cerevisiae (
Jones, Christopher Iain +2 more
core +1 more source
The Tumor Cytosol miRNAs, Fluid miRNAs, and Exosome miRNAs in Lung Cancer. [PDF]
, 2014 The focus of this review is to provide an update on the progress of microRNAs (miRNAs) as potential biomarkers for lung cancer. miRNAs are single-stranded, small non-coding RNAs that regulate gene expression and show tissue-specific signatures ...
Haisheng eXu +4 more
core +2 more sources
The exosome journey: from biogenesis to uptake and intracellular signalling
Cell Communication and Signaling, 2021 The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials testing exosomes for diagnostic and therapeutic applications are generating remarkable interest from the scientific community and investors.
Sonam Gurung +3 more
doaj +1 more source
Viruses and the cellular RNA decay machinery. [PDF]
, 2010 The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core +1 more source
The nuclear exosome is active and important during budding yeast meiosis.
PLoS ONE, 2014 Nuclear RNA degradation pathways are highly conserved across eukaryotes and play important roles in RNA quality control. Key substrates for exosomal degradation include aberrant functional RNAs and cryptic unstable transcripts (CUTs).
Stephen Frenk +2 more
doaj +1 more source
RST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis
Nature Communications, 2019 Cytosolic RNA degradation by the RNA exosome requires the Ski complex. Here the authors show that the proteins RST1 and RIPR assist the RNA exosome and the Ski complex in RNA degradation, thereby preventing the production of secondary siRNAs from ...
Heike Lange +15 more
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