Exosome and
Journal of Cellular and Molecular Medicine, 2023 AbstractThis short communication will enlighten the readers about the exosome and the epithelial‐mesenchymal transition (EMT) related to several complicated events. It also highlighted the therapeutic potential of exosomes against EMT. Exosome toxicology, exosome heterogeneity, and a single exosome profiling approach are also covered in this article ...
Rajib Dhar +5 more
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Understanding the complex role of exosomes in intestinal ischemia-reperfusion injury: from pathogenesis to protection. [PDF]
Front PharmacolYe Q, Yu ZH, Nie L, Wang FX, Mu G, Lu B.
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RNA Degradation by the Exosome Is Promoted by a Nuclear Polyadenylation Complex [PDF]
Cell, 2005 The exosome complex of 3'-5' exonucleases participates in RNA maturation and quality control and can rapidly degrade RNA-protein complexes in vivo. However, the purified exosome showed weak in vitro activity, indicating that rapid RNA degradation requires activating cofactors.
John LaCava +6 more
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The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma [PDF]
Arthritis Research & Therapy, 2000 The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75.
Rick Brouwer +2 more
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Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex. [PDF]
Mol Cell, 2016 The RNA exosome complex associates with nuclear and cytoplasmic cofactors to mediate the decay, surveillance, or processing of a wide variety of transcripts. In the cytoplasm, the conserved core of the exosome (Exo10) functions together with the conserved Ski complex. The interaction of S.
Kowalinski E +6 more
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Exosome Release by Glucose Deprivation Is Important for the Viability of TSC-Null Cells
Cells, 2022 The control of exosome release is associated with numerous physiological and pathological activities, and that release is often indicative of health, disease, and environmental nutrient stress.
Ji-Hyun Bae, Jong Hyun Kim
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Ferroptosis and Cancer: Complex Relationship and Potential Application of Exosomes [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cell death induction has become popular as a novel cancer treatment. Ferroptosis, a newly discovered form of cell death, features regulated, iron-dependent accumulation of lipid hydroperoxides. Since this word “ferroptosis” was coined, numerous studies have examined the complex relationship between ferroptosis and cancer.
Shuang Wu +4 more
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Development of Antibody–Oligonucleotide Complexes for Targeting Exosomal MicroRNA [PDF]
Pharmaceutics, 2020 MicroRNAs in exosomes (exosomal miRNAs) are considered as significant targets for cancer therapy. Anti-miR oligonucleotides are often used for the functional inhibition of miRNAs; however, there are no studies regarding the regulation of exosomal miRNA functions.
Eishi Ashihara +10 more
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Nab3 facilitates the function of the TRAMP complex in RNA processing via recruitment of Rrp6 independent of Nrd1. [PDF]
PLoS Genetics, 2015 Non-coding RNAs (ncRNAs) play critical roles in gene regulation. In eukaryotic cells, ncRNAs are processed and/or degraded by the nuclear exosome, a ribonuclease complex containing catalytic subunits Dis3 and Rrp6.
Milo B Fasken +2 more
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An exosome‐like complex in Sulfolobus solfataricus [PDF]
EMBO reports, 2003 We present the first experimental evidence for the existence of an exosome‐like protein complex in Archaea. In Eukarya, the exosome is essential for many pathways of RNA processing and degradation. Co‐immunoprecipitation with antibodies directed against the previously predicted Sulfolobus solfataricus orthologue of the exosome subunit ribosomal‐RNA ...
Pamela Walter +4 more
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