TGF-β suppression of HBV RNA through AID-dependent recruitment of an RNA exosome complex.
PLoS Pathogens, 2015 Transforming growth factor (TGF)-β inhibits hepatitis B virus (HBV) replication although the intracellular effectors involved are not determined.
Guoxin Liang +10 more
doaj +2 more sources
A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans. [PDF]
, 2016 The exosome complex is a major eukaryotic exoribonuclease that requires the SKI complex for its activity in the cytoplasm. In yeast, the Ski7 protein links both complexes, whereas a functional equivalent of the Ski7 has remained unknown in the human ...
Chlebowski, Aleksander +7 more
core +3 more sources
PLoS Genetics, 2020 Accurate target recognition in transcript degradation is crucial for regulation of gene expression. In the fission yeast Schizosaccharomyces pombe, a number of meiotic transcripts are recognized by a YTH-family RNA-binding protein, Mmi1, and selectively ...
Yuichi Shichino +3 more
doaj +2 more sources
RST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis
Nature Communications, 2019 Cytosolic RNA degradation by the RNA exosome requires the Ski complex. Here the authors show that the proteins RST1 and RIPR assist the RNA exosome and the Ski complex in RNA degradation, thereby preventing the production of secondary siRNAs from ...
Heike Lange +15 more
doaj +2 more sources
The exosome journey: from biogenesis to uptake and intracellular signalling
Cell Communication and Signaling, 2021 The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials testing exosomes for diagnostic and therapeutic applications are generating remarkable interest from the scientific community and investors.
Sonam Gurung +3 more
doaj +2 more sources
BMSC-Exosome/CGF Complex Enhances Bone Regeneration
International Dental JournalAim or purpose: Bone defect repair remains challenging. This study developed GelMA-CGF-EXOs composites integrating autologous CGF (from rat blood) and BMSC-derived EXOs to enhance bone regeneration.
Lanying Sun, Xinyang Liu
doaj +2 more sources
A budding yeast model for human disease mutations in the EXOSC2 cap subunit of the RNA exosome complex. [PDF]
RNA, 2021 Sterrett MC +13 more
europepmc +3 more sources
RNA Degradation Assay Using RNA Exosome Complexes, Affinity-purified from HEK-293 Cells
Bio-Protocol, 2017 The RNA exosome complex plays a central role in RNA processing and regulated turnover. Present both in cytoplasm and nucleus, the exosome functions through associations with ribonucleases and various adapter proteins (reviewed in [Kilchert et al., 2016]).
Michal Domanski, John LaCava
doaj +2 more sources
CRABP1-complexes in exosome secretion
Cell Communication and SignalingBackground Cellular retinoic acid binding protein 1 (CRABP1) mediates rapid, non-canonical activity of retinoic acid (RA) by forming signalosomes via protein-protein interactions.
Jennifer Nhieu +4 more
doaj +3 more sources
Distinct 18S rRNA precursors are targets of the exosome complex, the exoribonuclease RRP6L2 and the terminal nucleotidyltransferase TRL in Arabidopsis thaliana. [PDF]
The Plant Journal, 2015 Pawel J. Sikorski +7 more
semanticscholar +2 more sources