Results 291 to 300 of about 61,126 (326)

Role of exosomes in castration-resistant prostate cancer. [PDF]

Front Oncol
Cao Y, Wang J, Luo H, Wang Y, Cai X, Zhang T, Liao Y, Wang D.   +7 more
europepmc   +1 more source

Engineered exosomes: a promising drug delivery platform with therapeutic potential. [PDF]

Front Mol Biosci
Schwarz G, Ren X, Xie W, Guo H, Jiang Y, Zhang J.   +5 more
europepmc   +1 more source

Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high‐grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models

Cancer Communications, EarlyView.
Monika Raab, Balázs Győrffy, Samuel Peña‐Llopis, Daniela Fietz, Monika Kressin, Margareta Kolaric, Matthias Ebert, Khayal Gasimli, Sven Becker, Mourad Sanhaji, Klaus Strebhardt   +10 more
wiley   +1 more source

Activation of the Yeast Exosome Complex

, 2004
openaire   +1 more source

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Heterogeneous complexes of the RNA exosome in Sulfolobus solfataricus

Biochimie, 2012
The archaeal exosome is a protein complex involved in the degradation and the posttranscriptional tailing of RNA. The proteins Rrp41, Rrp42, Rrp4, Csl4 and DnaG are major subunits of the exosome in Sulfolobus solfataricus. In vitro, Rrp41 and Rrp42 form a catalytically active hexamer, to which an RNA-binding cap of Rrp4 and/or Csl4 is attached.
Verena Roppelt, Chamindri Witharana, Günther Lochnit, Gabriele Klug, Elena Evguenieva-Hackenberg   +4 more
openaire   +3 more sources

Comparison of the yeast and human nuclear exosome complexes

Biochemical Society Transactions, 2012
Most RNAs in eukaryotic cells are produced as precursors that undergo processing at the 3′ and/or 5′ end to generate the mature transcript. In addition, many transcripts are degraded not only as part of normal recycling, but also when recognized as aberrant by the RNA surveillance machinery.
Claudia Schneider, Katherine E. Sloan, Nicholas J. Watkins   +2 more
openaire   +3 more sources

In Vitro Characterization of the Prokaryotic Counterparts of the Exosome Complex

2019
The same basic set of enzymatic activities exhibited by the eukaryotic RNA exosome are also found in prokaryotes. Bacteria have two predominant and distinct 3'→5' exoribonuclease activities: one is characterized by processive hydrolysis, derived from RNase II and RNase R, and the other by processive phosphorolysis, derived from PNPase.
Rute G. Matos, Cecília M. Arraiano, Sandra C. Viegas   +2 more
openaire   +3 more sources

Exosome complex and pervasive transcription in eukaryotic genomes

Current Opinion in Cell Biology, 2009
Exosome complex is widely conserved, functionally versatile, and essential constituent of the machinery regulating gene expression in the nucleus as well as in the cytoplasm. While the most fundamental enzymatic property of exosome is ribonucleolytic activity, its in vivo functions are varied, highly specific, and tightly regulated, and include RNA ...
openaire   +3 more sources

Proteomic Analysis of Yeast Mutant RNA Exosome Complexes

Journal of Proteome Research, 2013
The yeast exosome is a conserved multiprotein complex essential for RNA processing and degradation. The complex is formed by a nine-subunit core that associates with two hydrolytic 3'-5' exoribonucleases. Although catalytically inert, the assembly of this nine-subunit core seems to be essential for the exosome activity, as mutations in regions that do ...
Rogério F. Lourenço, Carla C. Oliveira, Adriana Franco Paes Leme   +2 more
openaire   +3 more sources