Results 31 to 40 of about 315,886 (312)
Emerging Technologies for Cancer Research: Towards Personalized Medicine with Microfluidic Platforms and 3D Tumor Models [PDF]
Current Medicinal Chemistry, 2018, 2021 In the present review, we describe three hot topics in cancer research such as circulating tumor cells, exosomes, and 3D environment models. The first section is dedicated to microfluidic platforms for detecting circulating tumor cells, including both affinity based methods that take advantage of antibodies and aptamers, and label free approaches ...
arxiv +1 more source
An exosome‐like complex in Sulfolobus solfataricus [PDF]
EMBO reports, 2003 We present the first experimental evidence for the existence of an exosome‐like protein complex in Archaea. In Eukarya, the exosome is essential for many pathways of RNA processing and degradation. Co‐immunoprecipitation with antibodies directed against the previously predicted Sulfolobus solfataricus orthologue of the exosome subunit ribosomal‐RNA ...
Pamela Walter +4 more
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The nuclear exosome is active and important during budding yeast meiosis. [PDF]
PLoS ONE, 2014 Nuclear RNA degradation pathways are highly conserved across eukaryotes and play important roles in RNA quality control. Key substrates for exosomal degradation include aberrant functional RNAs and cryptic unstable transcripts (CUTs).
Stephen Frenk +2 more
doaj +1 more source
The regulation and functions of the nuclear RNA exosome complex [PDF]
Nature Reviews Molecular Cell Biology, 2016 The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes. The exosome has a central role in several aspects of RNA biogenesis, including RNA maturation and surveillance. Moreover, it is emerging as an important player in regulating the expression levels of specific mRNAs in response to environmental cues and during cell ...
Cornelia Kilchert +2 more
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Exosome complex and erythropoiesis [PDF]
Blood, 2014 In this issue of Blood , McIver et al demonstrate that components of the exosome complex are endogenous suppressors of erythroid maturation, revealing a new and novel regulatory mechanism for erythroid development.[1][1] ![Figure][2] Schematic model of GATA1/Foxo3-exosome complex network.
openaire +3 more sources
BMC Research Notes, 2019 Objective The RNA exosome is an evolutionarily conserved 3′–5′ exoribonucleolytic protein complex involved in processing and degradation of different classes of nuclear and cytoplasmic RNAs, and, therefore, important for the posttranscriptional control ...
J. S. Luz +7 more
doaj +1 more source
Exosome in Cardiovascular Diseases: A Complex World Full of Hope [PDF]
Cells, 2019 Exosomes are a subgroup of extracellular vesicles containing a huge number of bioactive molecules. They represent an important means of cell communication, mostly between different cell populations, with the purpose of maintaining tissue homeostasis and coordinating the adaptive response to stress.
Gloria Bellin +7 more
openaire +5 more sources
Musing on the structural organization of the exosome complex.
Nature structural biology, 2000 The exosome complex of 3'-->5' exoribonucleases functions in both the precise processing of 3' extended precursor molecules to mature stable RNAs and the complete degradation of other RNAs. Both processing and degradative activities of the exosome depend on additional cofactors, notably the putative RNA helicases Mtr4p and Ski2p.
Mitchell, Philip, Tollervey, David
openaire +4 more sources
PLoS Genetics, 2020 The RNA exosome is an evolutionarily-conserved ribonuclease complex critically important for precise processing and/or complete degradation of a variety of cellular RNAs.
Derrick J Morton +16 more
doaj +1 more source
A targeted siRNA‐loaded PDL1‐exosome and functional evaluation against lung cancer
Thoracic Cancer, 2022 Background As an endocytic nanosicle involved in intercellular communication, an exosome can efficiently deliver drugs from one cell to another and deliver therapeutic short interfering RNA (siRNA) to target cells.
Xianbin Lin +6 more
doaj +1 more source