Results 31 to 40 of about 61,126 (326)
An exosome‐like complex in Sulfolobus solfataricus [PDF]
EMBO reports, 2003 We present the first experimental evidence for the existence of an exosome‐like protein complex in Archaea. In Eukarya, the exosome is essential for many pathways of RNA processing and degradation. Co‐immunoprecipitation with antibodies directed against the previously predicted Sulfolobus solfataricus orthologue of the exosome subunit ribosomal‐RNA ...
Pamela Walter +4 more
openaire +3 more sources
Exosomes, autophagy, and cancer: A complex triad [PDF]
Int J CancerMaría Guerra‐Andrés +2 more
openalex +2 more sources
The regulation and functions of the nuclear RNA exosome complex [PDF]
Nature Reviews Molecular Cell Biology, 2016 The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes. The exosome has a central role in several aspects of RNA biogenesis, including RNA maturation and surveillance. Moreover, it is emerging as an important player in regulating the expression levels of specific mRNAs in response to environmental cues and during cell ...
Cornelia Kilchert +2 more
openaire +3 more sources
Development of Antibody–Oligonucleotide Complexes for Targeting Exosomal MicroRNA [PDF]
Pharmaceutics, 2020 MicroRNAs in exosomes (exosomal miRNAs) are considered as significant targets for cancer therapy. Anti-miR oligonucleotides are often used for the functional inhibition of miRNAs; however, there are no studies regarding the regulation of exosomal miRNA functions.
Eishi Ashihara +10 more
openaire +4 more sources
Exosome complex and erythropoiesis [PDF]
Blood, 2014 In this issue of Blood , McIver et al demonstrate that components of the exosome complex are endogenous suppressors of erythroid maturation, revealing a new and novel regulatory mechanism for erythroid development.[1][1] ![Figure][2] Schematic model of GATA1/Foxo3-exosome complex network.
openaire +3 more sources
The Exosome Subunit Rrp44 Plays a Direct Role in RNA Substrate Recognition [PDF]
, 2007 The exosome plays key roles in RNA maturation and surveillance, but it is unclear how target RNAs are identified. We report the functional characterization of the yeast exosome component Rrp44, a member of the RNase II family.
Anderson, James T. +2 more
core +2 more sources
Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control [PDF]
, 2019 Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure ...
Hughes, Katlyn D. +3 more
core +1 more source
The exosome complex establishes a barricade to erythroid maturation. [PDF]
Blood, 2014 Key Points Exosome complex components are endogenous suppressors of erythroid cell maturation. GATA-1 and Foxo3 transcriptionally repress exosome complex components, thus abrogating the erythroid maturation blockade.
McIver SC +11 more
europepmc +4 more sources
BMC Research Notes, 2019 Objective The RNA exosome is an evolutionarily conserved 3′–5′ exoribonucleolytic protein complex involved in processing and degradation of different classes of nuclear and cytoplasmic RNAs, and, therefore, important for the posttranscriptional control ...
J. S. Luz +7 more
doaj +1 more source
A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans. [PDF]
, 2016 The exosome complex is a major eukaryotic exoribonuclease that requires the SKI complex for its activity in the cytoplasm. In yeast, the Ski7 protein links both complexes, whereas a functional equivalent of the Ski7 has remained unknown in the human ...
Chlebowski, Aleksander +7 more
core +1 more source