Results 41 to 50 of about 62,378 (298)

Exosomes: Versatile Nano Mediators of Immune Regulation. [PDF]

, 2019
One of many types of extracellular vesicles (EVs), exosomes are nanovesicle structures that are released by almost all living cells that can perform a wide range of critical biological functions.
Cacalano, Nicholas A, Huyan, Ting, Li, Qi, Peng, Hourong, Wang, Helei   +4 more
core   +1 more source

Affinity Purification of the RNA Degradation Complex, the Exosome, from HEK-293 Cells

Bio-Protocol, 2017
The RNA exosome complex plays a central role in RNA processing and regulated turnover. Present both in cytoplasm and nucleus, the exosome functions through associations with ribonucleases and various adapter proteins (reviewed in [Kilchert et al., 2016]).
Michal Domanski, John LaCava
doaj   +1 more source

Digital detection of exosomes by interferometric imaging [PDF]

, 2016
Exosomes, which are membranous nanovesicles, are actively released by cells and have been attributed to roles in cell-cell communication, cancer metastasis, and early disease diagnostics.
Benussi, Luisa, Bettotti, Paolo, Chiari, Marcella, Ciani, Miriam, Cretich, Marina, Daaboul, George G., Freedman, David S., Gagni, Paola, Ghidoni, Roberta, Ozkumur, Ayca Yalcin, Piotto, Chiara, Prosperi, Davide, Santini, Benedetta, Unlu, M. Selim   +13 more
core   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

A cell-based assay for CD63-containing extracellular vesicles [PDF]

, 2019
Extracellular vesicles (EVs) are thought to be important in cell-cell communication and have elicited extraordinary interest as potential biomarkers of disease. However, quantitative methods to enable elucidation of mechanisms underlying release are few.
Cashikar, Anil G, Hanson, Phyllis I
core   +2 more sources

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity. [PDF]

, 2019
Mild traumatic brain injury (mTBI) disproportionately affects military service members and is very difficult to diagnose. To-date, there is currently no blood-based, diagnostic biomarker for mTBI cases with persistent post concussive symptoms. To examine
Baker, Dewleen G, Campana, Wendy, Conger, Tori, Ellisman, Maya, Hall, James R, Julovich, David A, Nauss, Sophie, Nievergelt, Caroline M, O'Bryant, Sid E, Risbrough, Victoria B, Rissman, Robert A, Romero, Haylie K, Winston, Charisse N   +12 more
core  

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release [PDF]

, 2017
Aims: Calcium phosphate (CaP) particle deposits are found in several inflammatory diseases including atherosclerosis and osteoarthritis. CaP, and other forms of crystals and particles, can promote inflammasome formation in macrophages leading to caspase ...
Afonina, Alexander N. Kapustin, Alfaidi, Bailet, Baroja-Mazo, Bautista Nino, Bennett, Burton, Catherine M. Shanahan, Chen, Cilla, Coopman, Cossetti, Cullen, Cunningham, Dautova, Diane Proudfoot, Duewell, Ehara, Erlinge, Ewence, Feil, Fuerst, Furman, Gross, Hanneke Okkenhaug, Hendriks, Hilgendorf, Hutcheson, Irkle, Iyemere, Jin, Kalra, Kapustin, Kevin Pappert, Kistowska, Krisenko, Laliberte, LaRocca, Lau, Li, Liu, Liu, Luga, Maldonado, Martin, Martin D. Bootman, Matthias Epple, Mfunyi, Migita, Mocsai, Molloy, Morgan, Nadra, Nakahara, Narayan, Ng, Pazar, Piccioli, Pugliese, Qu, Ragnauth, Ridker, Ruiz, Scimeca, Shamaa, Simon J. Cook, Smith, Song, Swaan, Vengrenyuk, Vigano, Virmani, Wang, Webber, Yana Dautova, Young   +76 more
core   +2 more sources