Results 41 to 50 of about 61,126 (326)
Musing on the structural organization of the exosome complex.
Nature structural biology, 2000 The exosome complex of 3'-->5' exoribonucleases functions in both the precise processing of 3' extended precursor molecules to mature stable RNAs and the complete degradation of other RNAs. Both processing and degradative activities of the exosome depend on additional cofactors, notably the putative RNA helicases Mtr4p and Ski2p.
Mitchell, Philip, Tollervey, David
openaire +4 more sources
Exosome in Cardiovascular Diseases: A Complex World Full of Hope [PDF]
Cells, 2019 Exosomes are a subgroup of extracellular vesicles containing a huge number of bioactive molecules. They represent an important means of cell communication, mostly between different cell populations, with the purpose of maintaining tissue homeostasis and coordinating the adaptive response to stress.
Gloria Bellin +7 more
openaire +5 more sources
The 3' to 5' exoribonuclease DIS3: from structure and mechanisms to biological functions and role in human disease [PDF]
, 2015 DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3’ to 5’ degradation and processing of both nuclear and cytoplasmic RNA species.
Carazo-Salas +7 more
core +2 more sources
PLoS Genetics, 2020 The RNA exosome is an evolutionarily-conserved ribonuclease complex critically important for precise processing and/or complete degradation of a variety of cellular RNAs.
Derrick J Morton +16 more
doaj +1 more source
RNA Turnover: Unexpected Consequences of Being Tailed [PDF]
, 2005 In eukaryotic cells, the 3′ poly(A) tails found on mRNA influence their stability and translation. The discovery of a second nuclear poly(A) polymerase complex has fueled a series of reports defining a new and unexpected role for 3′ end poly(A) tails in ...
Anderson, James T.
core +2 more sources
Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex [PDF]
Molecular Cell, 2011 The RNA exosome is a conserved degradation machinery, which obtains full activity only when associated with cofactors. The most prominent activator of the yeast nuclear exosome is the RNA helicase Mtr4p, acting in the context of the Trf4p/Air2p/Mtr4p polyadenylation (TRAMP) complex. The existence of a similar activator(s) in humans remains elusive.
Michał Lubas +8 more
openalex +7 more sources
A targeted siRNA‐loaded PDL1‐exosome and functional evaluation against lung cancer
Thoracic Cancer, 2022 Background As an endocytic nanosicle involved in intercellular communication, an exosome can efficiently deliver drugs from one cell to another and deliver therapeutic short interfering RNA (siRNA) to target cells.
Xianbin Lin +6 more
doaj +1 more source
Purification and analysis of endogenous human RNA exosome complexes [PDF]
RNA, 2016 As a result of its importance in key RNA metabolic processes, the ribonucleolytic RNA exosome complex has been the focus of intense study for almost two decades. Research on exosome subunit assembly, cofactor and substrate interaction, enzymatic catalysis and structure have largely been conducted using complexes produced in the yeast Saccharomyces ...
Michal Domanski +8 more
openaire +4 more sources
Certain Adenylated Non-Coding RNAs, Including 5′ Leader Sequences of Primary MicroRNA Transcripts, Accumulate in Mouse Cells following Depletion of the RNA Helicase MTR4 [PDF]
, 2014 RNA surveillance plays an important role in posttranscriptional regulation. Seminal work in this field has largely focused on yeast as a model system, whereas exploration of RNA surveillance in mammals is only recently begun.
Anderson, James T. +4 more
core +4 more sources
Viruses and the cellular RNA decay machinery. [PDF]
, 2010 The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core +1 more source