Results 41 to 50 of about 6,729,673 (335)
Development of Antibody–Oligonucleotide Complexes for Targeting Exosomal MicroRNA [PDF]
Pharmaceutics, 2020 MicroRNAs in exosomes (exosomal miRNAs) are considered as significant targets for cancer therapy. Anti-miR oligonucleotides are often used for the functional inhibition of miRNAs; however, there are no studies regarding the regulation of exosomal miRNA functions.
Asako Yamayoshi +9 more
openaire +3 more sources
Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex [PDF]
Molecular Cell, 2011 The RNA exosome is a conserved degradation machinery, which obtains full activity only when associated with cofactors. The most prominent activator of the yeast nuclear exosome is the RNA helicase Mtr4p, acting in the context of the Trf4p/Air2p/Mtr4p polyadenylation (TRAMP) complex. The existence of a similar activator(s) in humans remains elusive.
Lubas, Michal Szymon +8 more
openaire +5 more sources
A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex
bioRxiv, 2020 We describe the design of a small molecule that binds the structure of a r(CUG) repeat expansion [r(CUG)exp] and reverses molecular defects in two diseases mediated by the RNA - myotonic dystrophy type 1 (DM1) and Fuchs endothelial corneal dystrophy ...
Alicia J. Angelbello +11 more
semanticscholar +1 more source
Digital detection of exosomes by interferometric imaging [PDF]
, 2016 Exosomes, which are membranous nanovesicles, are actively released by cells and have been attributed to roles in cell-cell communication, cancer metastasis, and early disease diagnostics.
Benussi, Luisa +13 more
core +5 more sources
The Exosome Subunit Rrp44 Plays a Direct Role in RNA Substrate Recognition [PDF]
, 2007 The exosome plays key roles in RNA maturation and surveillance, but it is unclear how target RNAs are identified. We report the functional characterization of the yeast exosome component Rrp44, a member of the RNase II family.
Anderson, James T. +2 more
core +2 more sources
Certain Adenylated Non-Coding RNAs, Including 5′ Leader Sequences of Primary MicroRNA Transcripts, Accumulate in Mouse Cells following Depletion of the RNA Helicase MTR4 [PDF]
, 2014 RNA surveillance plays an important role in posttranscriptional regulation. Seminal work in this field has largely focused on yeast as a model system, whereas exploration of RNA surveillance in mammals is only recently begun.
Anderson, James T. +4 more
core +8 more sources
Ferroptosis and Cancer: Complex Relationship and Potential Application of Exosomes [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cell death induction has become popular as a novel cancer treatment. Ferroptosis, a newly discovered form of cell death, features regulated, iron-dependent accumulation of lipid hydroperoxides. Since this word “ferroptosis” was coined, numerous studies have examined the complex relationship between ferroptosis and cancer.
Shuang Wu +4 more
openaire +3 more sources
BMC Research Notes, 2019 Objective The RNA exosome is an evolutionarily conserved 3′–5′ exoribonucleolytic protein complex involved in processing and degradation of different classes of nuclear and cytoplasmic RNAs, and, therefore, important for the posttranscriptional control ...
J. S. Luz +7 more
doaj +1 more source
A Two-Layered Targeting Mechanism Underlies Nuclear RNA Sorting by the Human Exosome
Cell Reports, 2020 Summary: Degradation of transcripts in human nuclei is primarily facilitated by the RNA exosome. To obtain substrate specificity, the exosome is aided by adaptors; in the nucleoplasm, those adaptors are the nuclear exosome-targeting (NEXT) complex and ...
Guifen Wu +6 more
doaj +1 more source
Cell Reports, 2023 Summary: The RNA exosome is a versatile ribonuclease. In the nucleoplasm of mammalian cells, it is assisted by its adaptors the nuclear exosome targeting (NEXT) complex and the poly(A) exosome targeting (PAXT) connection.
Patrik Polák +11 more
doaj +1 more source