Results 51 to 60 of about 315,886 (312)
Cell Death Discovery, 2021 Exosomes have been associated with chemoresistance in various cancers, but such a role in ovarian cancer is not yet clear. Here, using in vitro cell-based and in vivo mouse model experiments, we show that downregulation of O-GlcNAcylation, a key post ...
Luomeng Qian +11 more
doaj +1 more source
Antibody-loading of biological nanocarrier vesicles derived from red-blood-cell membranes [PDF]
arXiv, 2023 Antibodies, disruptive potent therapeutic agents against pharmacological targets, face a barrier crossing immune-system and cellular-membranes. To overcome these, various strategies have been explored including shuttling via liposomes or bio-camouflaged nanoparticles.
arxiv
Plasmonic nano-aperture label-free imaging [PDF]
, 2020 Label-free observation of nanoparticles by far-field optical microscopy is challenging because their ability to scatter or absorb light dramatically diminishes with decreasing size. Surface plasmon resonance (SPR) and localized surface plasmon resonance (LSPR) imaging have shown promises and respective limitations.
arxiv +1 more source
Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase
Cell Reports, 2017 The RNA-degrading exosome mediates the processing and decay of many cellular transcripts. In the yeast nucleus, the ubiquitous 10-subunit exosome core complex (Exo-9–Rrp44) functions with four conserved cofactors (Rrp6, Rrp47, Mtr4, and Mpp6 ...
Sebastian Falk +4 more
doaj +1 more source
Proposal of Absolute Nanometer Size Measurement in Flow Cytometry Based on Laser Interferometry [PDF]
arXiv, 2021 The author discusses the laser interference method to measure the size of small bio-particles: extracellular vesicles (EVs), exosomes and viruses of nanometer scale in flow cytometry. By introducing a new laser configuration in place of conventional optical system of the flow cytometry, the interference fringe (periodic intensity modulation) is created
arxiv
iCLIP analysis of RNA substrates of the archaeal exosome
BMC Genomics, 2020 Background The archaeal exosome is an exoribonucleolytic multiprotein complex, which degrades single-stranded RNA in 3′ to 5′ direction phosphorolytically. In a reverse reaction, it can add A-rich tails to the 3′-end of RNA.
Jochen Bathke +9 more
doaj +1 more source
Acoustofluidics for simultaneous nanoparticle-based drug loading and exosome encapsulation
Microsystems & Nanoengineering, 2022 Nanocarrier and exosome encapsulation has been found to significantly increase the efficacy of targeted drug delivery while also minimizing unwanted side effects.
Zeyu Wang +7 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Pharmaceuticals, 2021 Exosomes are nano-sized extracellular vesicles produced and released by almost all cell types. They play an essential role in cell–cell communications by delivering cellular bioactive compounds such as functional proteins, metabolites, and nucleic acids,
Erika Cione +4 more
doaj +1 more source
The human cap-binding complex is functionally connected to the nuclear RNA exosome [PDF]
Nature Structural & Molecular Biology, 2013 Nuclear processing and quality control of eukaryotic RNA is mediated by the RNA exosome, which is regulated by accessory factors. However, the mechanism of exosome recruitment to its ribonucleoprotein (RNP) targets remains poorly understood. Here we report a physical link between the human exosome and the cap-binding complex (CBC).
Evgenia Ntini +19 more
openaire +8 more sources