Results 81 to 90 of about 315,886 (312)

Unveiling the Complex Role of Exosomes in Alzheimer’s Disease

Journal of Inflammation Research
Alzheimer's disease (AD) is the most common neurodegenerative illness, characterized by memory loss and cognitive decline, accounting for 60-80% of dementia cases. AD is characterized by senile plaques made up of amyloid β (Aβ) protein, intracellular neurofibrillary tangles caused by hyperphosphorylation of tau protein linked with microtubules, and ...
Sun, Mingyue, Chen, Zhuoyou
openaire   +2 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Exocyst controls exosome biogenesis via Rab11a

Molecular Therapy: Nucleic Acids, 2022
Tumor cells actively release large quantities of exosomes, which pivotally participate in the regulation of cancer biology, including head and neck cancer (HNC). Exosome biogenesis and release are complex and elaborate processes that are considered to be
Suwen Bai, Wenxuan Hou, Yanheng Yao, Jialin Meng, Yuan Wei, Fangfang Hu, Xianyu Hu, Jing Wu, Ning Zhang, Ruihuan Xu, Faqing Tian, Benguo Wang, Hailan Liao, Yinan Du, Haoshu Fang, Wei He, Yehai Liu, Bing Shen, Juan Du   +18 more
doaj  

Biophysical characterization of membrane phase transition profiles for the discrimination of Outer Membrane Vesicles (OMVs) from Escherichia coli grown at different temperatures [PDF]

arXiv, 2019
Dynamic Light Scattering (DLS), Small Angle X-ray Scattering (SAXS) and Transmission Electron Microscopy (TEM) are physical techniques widely employed to characterize the morphology and the structure of vesicles such as liposomes or human extracellular vesicles (exosomes). Bacterial extracellular vesicles are similar in size to human exosomes, although
arxiv  

Structure determination of an 11-subunit exosome in complex with RNA by molecular replacement [PDF]

Acta Crystallographica Section D Biological Crystallography, 2013
The RNA exosome is an evolutionarily conserved multi-protein complex involved in the 3′ degradation of a variety of RNA transcripts. In the nucleus, the exosome participates in the maturation of structured RNAs, in the surveillance of pre-mRNAs and in the decay of a variety of noncoding transcripts.
Debora Lika Makino, Elena Conti
openaire   +4 more sources

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review

Discover Oncology, 2022
Exosomes can be released by a variety of cells and participate in intercellular communication in many physiological processes in the body. They can be used as carriers of cancer therapeutic drugs and have natural delivery capabilities.
Zhen Fang, Yixuan Ding, Zhigang Xue, Peijuan Li, Jia Li, Fei Li   +5 more
doaj   +1 more source

TLR-exosomes exhibit distinct kinetics and effector function [PDF]

arXiv, 2016
The innate immune system is vital to rapidly responding to pathogens and Toll-like receptors (TLRs) are a critical component of this response. Nanovesicular exosomes play a role in immunity, but to date their exact contribution to the dissemination of the TLR response is unknown.
arxiv  

Oriented Getzler-Kapranov complexes and framed curves [PDF]

arXiv, 2022
In the present paper, we introduce and study oriented Getzler-Kapranov complexes. These complexes are generalizations of S. Merkulov's oriented graph complex. We investigate their relation to the cohomology of moduli spaces of complex and tropical curves, ribbon graph complexes, and motivic structures in string topology.
arxiv  

Multidirectionally Patterned Interdigital Transducers for Enhancing Acoustofluidic Streaming with Flexible Printed Circuit Board

Advanced Functional Materials, EarlyView.
A reconfigurable and multidirectional interdigital transducer (M‐IDT) on a flexible printed circuit board provides a practical platform for acoustofluidic research. It simplifies and accelerates prototyping, enabling cost‐effective exploration of wave modes and fluid dynamics.
Mercedes Stringer, Povilas Dumčius, Xiaoyan Zhang, Yanyan Chai, Ziming Zeng, Zhiqiang Dong, Chao Sun, Dongfang Liang, Guangbo Ge, Yongqing Fu, Zhenlin Wu, Xin Yang   +11 more
wiley   +1 more source