Results 91 to 100 of about 2,624 (190)

Cell adhesion inArabidopsis thalianais mediated by ECTOPICALLY PARTING CELLS 1 – a glycosyltransferase (GT64) related to the animal exostosins [PDF]

The Plant Journal, 2005
SummaryDespite the fact that several hundred glycosyltransferases have been identified from sequencing of plant genomes, the biological functions of only a handful have been established to date. A Poplar glycosyltransferase 64 (GT64) family member that is differentially expressed during the cell division and elongation phases of cambial growth was ...
Singh, Sunil Kumar, Eland, Cathlene, Harholt, Jesper, Scheller, Henrik Vibe, Marchant, Alan   +4 more
openaire   +3 more sources

Alveolar Glycocalyces During Health and Critical Illness

Proteoglycan Research, Volume 3, Issue 1, January-March 2025.
ABSTRACT The alveolus, the functional unit of the lung, is comprised of closely approximated alveolar epithelial and endothelial cells, across which gas exchange occurs. This alveolar septum also includes two substantial, intraluminal extracellular matrices: the alveolar epithelial and endothelial glycocalyces.
Yimu Yang, Eric P. Schmidt
wiley   +1 more source

Abnormal sodium and water homeostasis in mice with defective heparan sulfate polymerization.

PLoS ONE, 2019
Glycosaminoglycans in the skin interstitium and endothelial surface layer have been shown to be involved in local sodium accumulation without commensurate water retention. Dysfunction of heparan sulfate glycosaminoglycans may therefore disrupt sodium and
Rik H G Olde Engberink, Judith de Vos, Angela van Weert, Yahua Zhang, Naomi van Vlies, Bert-Jan H van den Born, Jens M Titze, Ed van Bavel, Liffert Vogt   +8 more
doaj   +1 more source

Development of a Proteomic Workflow for the Identification of Heparan Sulphate Proteoglycan‐Binding Substrates of ADAM17

PROTEOMICS, Volume 24, Issue 23-24, December 2024.
ABSTRACT Ectodomain shedding, which is the proteolytic release of transmembrane proteins from the cell surface, is crucial for cell‐to‐cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding of over 50 transmembrane proteins ranging from cytokines and growth factors, such as TNF and EGFR ligands, to ...
Matteo Calligaris, Donatella Pia Spanò, Maria Chiara Puccio, Stephan A. Müller, Simone Bonelli, Margot Lo Pinto, Giovanni Zito, Carl P. Blobel, Stefan F. Lichtenthaler, Linda Troeberg, Simone Dario Scilabra   +10 more
wiley   +1 more source

Chondrosarcoma transformation in hereditary multiple exostoses: A systematic review and clinical and cost-effectiveness of a proposed screening model

Journal of Bone Oncology, 2018
Background: The most serious complication of hereditary multiple exostoses(HME) is chondrosarcoma transformation. Numerous authors have suggested that screening might allow early chondrosarcoma detection.
Li Fei, Clara Ngoh, Daniel E. Porter
doaj   +1 more source

A STAT3 Gene Expression Signature in Gliomas is Associated with a Poor Prognosis [PDF]

, 2013
Gliomas frequently display constitutive activation of the transcription factor STAT3, a protein that is known to be able to mediate neoplastic transformation.
Alvarez, James V., Black, Peter McLaren, Chakladar, Abhijit, Chakravarti, Arnab, Frank, David A., Loeffler, Jay S, Mukherjee, Neelanjan, Robe, Pierre, Zhai, Gary   +8 more
core  

Unveiling the GT114 family: Structural characterization of A075L, a glycosyltransferase from Paramecium bursaria chlorella virus‐1 (PBCV‐1)

Protein Science, Volume 33, Issue 12, December 2024.
Abstract Protein A075L is a β‐xylosyltransferase that participates in producing the core of the N‐glycans found in VP54, the major viral capsid protein of Paramecium bursaria chlorella virus‐1 (PBCV‐1). In this study, we present an X‐ray crystallographic analysis of the apo form of A075L, along with its complexes with the sugar donor and with a ...
Maria Elena Laugieri, Immacolata Speciale, Ana Gimeno, Sicheng Lin, Brock W. Byers, Ana Poveda, Reyes Núñez‐Franco, Idoia Iturrioz, María J. Moure, Gonzalo Jiménez‐Osés, Irene Russo‐Krauss, Anna Notaro, James L. Van Etten, Todd L. Lowary, Jesús Jimenez‐Barbero, Cristina De Castro, Michela Tonetti, Adriana L. Rojas   +17 more
wiley   +1 more source

A splice mutation and mRNA decay of EXT2 provoke hereditary multiple exostoses.

PLoS ONE, 2014
BackgroundHereditary multiple exostoses (HME) is an autosomal dominant disease. The classical paradigm of mutation screening seeks to relate alterations in the exostosin glycosyltransferase genes, EXT1 and EXT2, which are responsible for over 70% of HME ...
Chen Tian, Rengna Yan, Shuzhen Wen, Xueling Li, Tianfeng Li, Zhenming Cai, Xinxiu Li, Hong Du, Huimei Chen   +8 more
doaj   +1 more source

Biology of bone sarcomas and new therapeutic developments [PDF]

, 2017
Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities.
Brown, H.K., Gouin, F., Heymann, D., Heymann, M.-F., Schiavone, K.   +4 more
core   +1 more source

#1267 Exostosin 1- and 2-positive membranous nephropathy in Chinese patients

Nephrology Dialysis Transplantation
Abstract Background and Aims The exostosin 1 and 2 (EXT1/2) complex was recently identified as a potential antigen associated with systemic autoimmunity in PLA2R-negative membranous nephropathy patients.
Guoqin Wang, Lijun Sun, Xiaoyi Xu, Nan Ye, Min Yang, Yanyan Wang, Wenrong Cheng, Zhirui Zhao, Xiaoyi Zhao, Yanqiu Geng, Feng Mei, Hong Cheng   +11 more
openaire   +1 more source