Results 1 to 10 of about 25,344,123 (207)

Donor substrate promiscuity of bacterial β1–3-N-acetylglucosaminyltransferases and acceptor substrate flexibility of β1–4-galactosyltransferases [PDF]

Bioorganic and Medicinal Chemistry, 2016
β1–3-N-Acetylglucosaminyltransferases (β3GlcNAcTs) and β1–4-galactosyltransferases (β4GalTs) have been broadly used in enzymatic synthesis of N-acetyllactosamine (LacNAc)-containing oligosaccharides and glycoconjugates including poly-LacNAc, and lacto-N ...
Xi Chen, Hai Yu, Yanhong Li
exaly   +7 more sources

Ablation of N-acetylglucosaminyltransferases in Caenorhabditis induces expression of unusual intersected and bisected N-glycans. [PDF]

Biochim Biophys Acta Gen Subj, 2018
The modification in the Golgi of N-glycans by N-acetylglucosaminyltransferase I (GlcNAc-TI, MGAT1) can be considered to be a hallmark of multicellular eukaryotes as it is found in all metazoans and plants, but rarely in unicellular organisms.
Yan S, Wang H, Schachter H, Jin C, Wilson IBH, Paschinger K.   +5 more
europepmc   +4 more sources

Implication of N-acetylglucosaminyltransferases III and V in cancer: gene regulation and signaling mechanism [PDF]

Biochimica Et Biophysica Acta - Molecular Basis of Disease, 1999
N-acetylglucosaminyltransferases III (GnT-III) and V (GnT-V) play a pivotal role in the processing of N-linked glycoproteins, and are highly involved in cancer progression and metastasis.
Naoyuki Taniguchi, Yoshito Ihara, Eiji Miyoshi   +2 more
exaly   +3 more sources

Enzymes for N-Glycan Branching and Their Genetic and Nongenetic Regulation in Cancer [PDF]

Biomolecules, 2016
N-glycan, a fundamental and versatile protein modification in mammals, plays critical roles in various physiological and pathological events including cancer progression.
Yasuhiko Kizuka, Naoyuki Taniguchi
doaj   +3 more sources

Core 2 β1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity [PDF]

Biochemistry and Biophysics Reports, 2021
Hyperglycosylated human chorionic gonadotropin (H-hCG) is secreted from choriocarcinoma and contains a core2 O-glycan formed by core2 β1,6-N-acetylglucosaminyl transferase (C2GnT).
Kenichi Nakamura, Kaoru Niimi, Eiko Yamamoto, Yoshiki Ikeda, Kimihiro Nishino, Shiro Suzuki, Hiroaki Kajiyama, Fumitaka Kikkawa   +7 more
doaj   +2 more sources

N-acetylglucosaminyltransferases and nucleotide sugar transporters form multi-enzyme-multi-transporter assemblies in golgi membranes in vivo. [PDF]

Cell Mol Life Sci, 2019
Branching and processing of N-glycans in the medial-Golgi rely both on the transport of the donor UDP-N-acetylglucosamine (UDP-GlcNAc) to the Golgi lumen by the SLC35A3 nucleotide sugar transporter (NST) as well as on the addition of the GlcNAc residue ...
Khoder-Agha F, Sosicka P, Escriva Conde M, Hassinen A, Glumoff T, Olczak M, Kellokumpu S.   +6 more
europepmc   +2 more sources

Specific N-glycans of Hepatocellular Carcinoma Cell Surface and the Abnormal Increase of Core-α-1, 6-fucosylated Triantennary Glycan via N-acetylglucosaminyltransferases-IVa Regulation. [PDF]

Sci Rep, 2015
Glycosylation alterations of cell surface proteins are often observed during the progression of malignancies. The specific cell surface N-glycans were profiled in hepatocellular carcinoma (HCC) with clinical tissues (88 tumor and adjacent normal tissues)
Nie H, Liu X, Zhang Y, Li T, Zhan C, Huo W, He A, Yao Y, Jin Y, Qu Y, Sun XL, Li Y.   +11 more
europepmc   +2 more sources

N-Glycoengineering of insect cells for tri-antennary N-glycan biosynthesis [PDF]

Scientific Reports
Insect cells are attractive hosts for biopharmaceutical production due to their high productivity and mammalian-like post-translational modifications.
Hiroyuki Kajiura, Naokuni Nishiguchi, Reimi Lai Sang Sawada-Choi, Yuto Sana, Ryo Misaki, Kazuhito Fujiyama   +5 more
doaj   +2 more sources

Evolutionary analyses of the animal glycosyltransferase family 54 reveals two β1,4-N-acetylglucosaminyltransferase families [PDF]

iScience
Summary: N-acetylglucosaminyltransferases involved in branched N-glycans synthesis, a major post-translational modification, are gathered in the CAZy glycosyltransferase family 54.
Aoi Morigo, Roxana Elin Teppa, Masamichi Nagae, Hirokazu Yagi, Yasuhiko Kizuka, Anne Harduin-Lepers   +5 more
doaj   +2 more sources

Identification and Characterization of Three Novel β1,3-N-Acetylglucosaminyltransferases Structurally Related to the β1,3-Galactosyltransferase Family

Journal of Biological Chemistry, 2001
We have isolated three types of cDNAs encoding novel β1,3-N-acetylglucosaminyltransferases (designated β3Gn-T2, -T3, and -T4) from human gastric mucosa and the neuroblastoma cell line SK-N-MC.
Hisashi Narimatsu, Akira Togayachi, Katsutoshi Sasaki   +2 more
exaly   +2 more sources