Results 11 to 20 of about 2,624 (190)

Exostosin 1 Knockdown Induces Chemoresistance in MV3 Melanoma Cells by Upregulating JNK and MEK/ERK Signaling. [PDF]

Int J Mol Sci, 2023
Heparan sulfate proteoglycans (HSPGs) possess various functions driving malignancy of tumors. However, their impact on tumor cell sensitivity to cytotoxic treatment is far less understood. Aiming to investigate this, we depleted HSPGs by downregulating Exostosin 1 (EXT1), a key enzyme in HS formation, or upregulating heparanase in human MV3 human ...
Pfeifer V, Weber H, Wang Y, Schlesinger M, Gorzelanny C, Bendas G.   +5 more
europepmc   +4 more sources

Treatment of exostosin 1-associated membranous lupus nephritis with multiple low doses of rituximab: A case report. [PDF]

Medicine (Baltimore), 2021
Abstract Rationale: Membranous glomerulonephritis (MN) is the leading cause of nephrotic syndrome in adults and is classified as primary or secondary. Secondary MN accounts for 20% to 30% of all MN cases and can arise from a number of conditions, including autoimmune diseases.
Li L, Yang Z, Tao T, Yang M, Hu ZX.
europepmc   +3 more sources

Exostosin 1 regulates cancer cell stemness in doxorubicin-resistant breast cancer cells. [PDF]

Oncotarget, 2017
Cancer stem cells (CSCs) are associated with cancer recurrence following radio/chemotherapy owing to their high resistance to therapeutic intervention. In this study, we investigated the role of exostoxin 1 (EXT1), an endoplasmic reticulum (ER)-residing type II transmembrane glycoprotein, in cancer cell stemness.
Manandhar S, Kim CG, Lee SH, Kang SH, Basnet N, Lee YM.   +5 more
europepmc   +4 more sources

Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans. [PDF]

PLoS Genetics, 2017
The regulation of cell migration is essential to animal development and physiology. Heparan sulfate proteoglycans shape the interactions of morphogens and guidance cues with their respective receptors to elicit appropriate cellular responses.
Cassandra R Blanchette, Andrea Thackeray, Paola N Perrat, Siegfried Hekimi, Claire Y Bénard   +4 more
doaj   +5 more sources

Exostosin 1 is expressed in human odontoblasts [PDF]

Archives of Oral Biology, 2017
Objective: Dental pulp is soft connective tissue maintaining the vitality of the tooth, while odontoblasts form the dentin. Our earlier DNA microarray analysis revealed expression of putative tumour suppressor exostosin 1 (EXT-1) in odontoblasts.
Bleicher, Francoise, Nevo, Zvi, Paakkonen, Virve, Saraniemi, Stina, Tjaderhane, Leo   +4 more
core   +4 more sources

Dual roles of exostosin glycosyltransferase 1 in Zika virus infection

Virulence
Many factors involved in heparan sulfate (HS) biosynthesis and metabolism have been reported to play roles in viral infection. However, the detailed mechanisms are still not fully understood. In this study, we report that exostosin glycosyltransferase 1 (
Jiaxin Ling, Asifa Khan, Matthias Denkewitz, Marco Maccarana, Åke Lundkvist, Jin-Ping Li, Jinlin Li   +6 more
doaj   +4 more sources

Lupus-like membranous nephropathy during the postpartum period expressing glomerular antigens exostosin 1/exostosin 2 and phospholipase A2 receptor: a case report. [PDF]

CEN Case Rep
Recently, several target antigens of membranous nephropathy (MN), such as phospholipase A2 receptor (PLA2R) and exostosin 1/exostosin 2 (EXT1/2), have been discovered. A 30-year-old woman was referred to our hospital with nephrotic range proteinuria and microscopic hematuria. She was first noted to have proteinuria before pregnancy, and her proteinuria
Miyasaka R, Wada Y, Takeuchi K, Abe T, Uchitsubo R, Kawamura S, Sakurabayashi S, Naito S, Aoyama T, Shimizu A, Takeuchi Y.   +10 more
europepmc   +3 more sources

Targeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid

Cell Death and Disease, 2023
Transglutaminase 2 (TG2) is a multifunctional protein that promotes or suppresses tumorigenesis, depending on intracellular location and conformational structure.
Xian-Yang Qin, Yutaka Furutani, Kento Yonezawa, Nobutaka Shimizu, Miyuki Kato-Murayama, Mikako Shirouzu, Yali Xu, Yumiko Yamano, Akimori Wada, Luc Gailhouste, Rajan Shrestha, Masataka Takahashi, Jeffrey W. Keillor, Ting Su, Wenkui Yu, Shinya Fujii, Hiroyuki Kagechika, Naoshi Dohmae, Yohei Shirakami, Masahito Shimizu, Takahiro Masaki, Tomokazu Matsuura, Harukazu Suzuki, Soichi Kojima   +23 more
doaj   +3 more sources

Retrospective analysis of serum NELL-1 and EXT1/2: no significant predictive value for treatment response in a cohort of membranous nephropathy patients [PDF]

Renal Failure
Neural epidermal growth factor-like protein 1 (NELL-1) and the exostosin 1/2 complex (EXT1/2) are recently identified target antigens in membranous nephropathy (MN), yet their prevalence and clinical features in Chinese populations remain poorly ...
Yemei Dai, Rongrong Feng, Xiaowen Duan, Xiaole Su, Lihua Wang   +4 more
doaj   +2 more sources

Case Report of the positive exostosin-1 without B-cell lymphoma-2 gene expression of giant cell tumor lesion in hereditary multiple exostosis. [PDF]

Int J Surg Case Rep, 2016
The giant cell tumor, in which BCL-2 gene was expressed only in its malignant transformation, is a benign, primary skeletal neoplasm with variable biologic aggressiveness. The is of the giant cell tumor. A coexistence with hereditary multiple exostosis with expression of EXT-1 is very rare.
Eka Wiratnaya IG, Aditya Gitapradita B NG, Yudhi Setiawan IGN, Suyasa IK, Siki Kawiyana IK, Astawa P.   +5 more
europepmc   +3 more sources