Structural Features of Glypicans and their Impact on Wnt Signaling in Cancer. [PDF]
Proteoglycan ResABSTRACT Glypicans (GPCs) are a family of cell surface proteoglycans involved in multiple signaling pathways that regulate cell fate and proliferation. They share a characteristic structure composed of a core protein with two or more heparan sulfate chains and a glycosyl‐phosphatidylinositol anchor that attaches them to the cell membrane.
Tsao HE, Ho M.
europepmc +2 more sources
Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis [PDF]
, 2014 Impaired heparan sulfate (HS) synthesis in vertebrate development causes complex malformations due to the functional disruption of multiple HS-binding growth factors and morphogens.
Carbe, Christian +12 more
core +1 more source
Medicina, 2022 Background and Objectives: Hereditary multiple exostoses (HME) is a disease characterized by cartilage-capped bony protuberances at the site of growth plates of long bones.
Muhammad Ajmal +5 more
doaj +1 more source
Genome-wide identification of pistil-specific genes expressed during fruit set initiation in tomato (Solanum lycopersicum) [PDF]
, 2017 Fruit set involves the developmental transition of an unfertilized quiescent ovary in the pistil into a fruit. While fruit set is known to involve the activation of signals (including various plant hormones) in the ovary, many biological aspects of this ...
Ariizumi Tohru +8 more
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Whole genome semiconductor based sequencing of farmed European sea bass (Dicentrarchus labrax) Mediterranean genetic stocks using a DNA pooling approach [PDF]
, 2016 European sea bass (Dicentrarchus labrax) is an important marine species for commercial and sport fisheries and aquaculture production. Recently, the European sea bass genome has been sequenced and assembled.
Bertolini, F +5 more
core +1 more source
The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis [PDF]
, 2022 : Heparan sulfate is a highly modified O-linked glycan that performs diverse physiological roles in animal tissues. Though quickly modified, it is initially synthesised as a polysaccharide of alternating β-d-glucuronosyl and N-acetyl-α-d-glucosaminyl ...
Chirgadze, D. Y. +10 more
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Heterogeneity of Target Antigens in Sarcoidosis-Associated Membranous Nephropathy [PDF]
, 2023 Introduction: Membranous nephropathy (MN) is the most common glomerular disease associated with sarcoidosis. The target antigen M-type phospholipase A2 receptor 1 (PLA2R) has been identified in a subset of sarcoidosis-associated MN. The target antigen is
Fervenza, Fernando C. +6 more
core +1 more source
Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation [PDF]
, 2012 The pocket proteins pRB, p107 and p130 have established roles in regulating the cell cycle through the control of E2F activity. The pocket proteins regulate differentiation of a number of tissues in both cell cycle-dependent and -independent manners ...
Danielian, Paul S. +2 more
core +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka +4 more
wiley +1 more source
Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. [PDF]
, 2019 Hepcidin is a liver-derived peptide hormone that controls systemic iron homeostasis. Its expression is regulated by the bone morphogenetic protein 6 (BMP6)/SMAD1/5/8 pathway and by the proinflammatory cytokine interleukin 6 (IL6).
Anower-E-Khuda, Ferdous +8 more
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