Results 61 to 70 of about 2,624 (190)

Pan-cancer analysis of the prognostic and immunotherapeutic values of exostosin-1

, 2023
Abstract Background Exostosin-1 (EXT1) is associated with the spread and metastasis of cancer cells. In this study, we investigate the prognostic value and immunological relevance of EXT1 in various cancers.Methods The expression profiles and clinical data of 33 different cancers were collected.
Yuqiu Liu, Li Li, Hongqing Wang, Wei Tian, Qingfeng Lv, Yujie Zhang, Changzhong Li   +6 more
openaire   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Transcriptomics in Venous Leg Ulcers (VLU): A Systematic Review

Wound Repair and Regeneration, Volume 34, Issue 2, March/April 2026.
ABSTRACT Venous leg ulcers (VLUs) are chronic wounds in the lower limbs that cause significant morbidity. The underlying biology underpinning non‐healing in VLUs is still poorly understood and differences in transcriptomic profiles may help elucidate biological pathways involved in wound chronicity.
Chien Lin Soh, Kia Hau Matthew Tan, Alun Huw Davies, Sarah Onida   +3 more
wiley   +1 more source

An investigation of genetic polymorphisms in heparan sulfate proteoglycan core proteins and key modification enzymes in an Australian Caucasian multiple sclerosis population

Human Genomics, 2020
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system in young adults. Heparan sulfate proteoglycans (HSPGs) are ubiquitous to the cell surface and the extracellular matrix.
Rachel K. Okolicsanyi, Julia Bluhm, Cassandra Miller, Lyn R. Griffiths, Larisa M. Haupt   +4 more
doaj   +1 more source

Clinical and Genetic Significance of Chromosomal Microarray Screening of Asymptomatic Newborns

Journal of Clinical Laboratory Analysis, Volume 40, Issue 3, February 2026.
Among 99 asymptomatic newborns with abnormal low‐resolution chromosomal microarray (LR‐CMA) screening, 70.7% harbored microduplication/microdeletions with syndromic implications. However, only a minority exhibited developmental concerns during early follow‐up, highlighting the need for cautious interpretation.
Naye Choi, Hwa Young Kim, Jung Min Ko
wiley   +1 more source

EXT1 as an Independent Prognostic Biomarker in Breast Cancer: Its Correlation with Immune Infiltration and Clinicopathological Parameters

Immuno
Exostosin 1 (EXT1) encodes a type II transmembrane glycosyltransferase residing in the endoplasmic reticulum and plays an essential role in the elongation of heparan sulfate chain biosynthesis. Additionally, EXT1 may act as an oncogene that could promote
Amira Hossny, Hatem A. F. M. Hassan, Sherif Ashraf Fahmy, Hazem Abdelazim, Mahmoud Mohamed Kamel, Ahmed H. Osman, Sherif Abdelaziz Ibrahim   +6 more
doaj   +1 more source

Heparanase and Syndecan-4 Are Involved in Low Molecular Weight Fucoidan-Induced Angiogenesis

Marine Drugs, 2015
Induction of angiogenesis is a potential treatment for chronic ischemia. Low molecular weight fucoidan (LMWF), the sulfated polysaccharide from brown seaweeds, has been shown to promote revascularization in a rat limb ischemia, increasing angiogenesis ...
Oualid Haddad, Erwan Guyot, Nicolas Marinval, Fabien Chevalier, Loïc Maillard, Latifa Gadi, Christelle Laguillier-Morizot, Olivier Oudar, Angela Sutton, Nathalie Charnaux, Hanna Hlawaty   +10 more
doaj   +1 more source

Identification of the genes chemosensitizing hepatocellular carcinoma cells to interferon-α/5-fluorouracil and their clinical significance. [PDF]

PLoS ONE, 2013
The incidence of advanced hepatocellular carcinoma (HCC) is increasing worldwide, and its prognosis is extremely poor. Interferon-alpha (IFN-α)/5-fluorouracil (5-FU) therapy is reportedly effective in some HCC patients.
Tomohiko Sakabe, Hiroyuki Tsuchiya, Keita Kanki, Junya Azumi, Kazue Gonda, Yusuke Mizuta, Daisaku Yamada, Hiroshi Wada, Kohei Shomori, Hiroaki Nagano, Goshi Shiota   +10 more
doaj   +1 more source

The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications [PDF]

, 2005
Background: Rice is an important staple food and, with the smallest cereal genome, serves as a reference species for studies on the evolution of cereals and other grasses. Therefore, decoding its entire genome will be a prerequisite for applied and basic
Batra, K., Bera, J., Bhargava, A., Bharti, A. K., Buell, C. R., Cattolico, L., Choisne, N., Collura, K., Couloux, A., Currie, J., D'Hont, A., Dalal, V., de Vazeille, A. R., Demange, N., Dike, S., Dixit, A., Dixit, R., Du, C., Fadrosh, D., Feldblyum, T., Fraser, C., Fuks, G., Gaikwad, K., Gaur, A., Ghaz, I. A., Gupta, V., Haas, B., Hamilton, J., Hsiao, J., Iobst, S., Jiang, J. M., Jin, W. W., Johri, S., Jones, K. M., Kapur, A., Khurana, J. P., Khurana, P., Kim, H. R., Kim, M., Kramer, M., Kudrna, D., Kumar, D., Lewis, M., Lin, H. N., Linton, E., Liu, J., Matsumoto, T., McCombie, W. R., Mendiratta, S. D., Messing, J., Mizuno, H., Mohanty, A., Mohapatra, T., Mueller, C., Namiki, N., Nascimento, L., O'Shaughnessy, A., Orjeda, G., Ouyang, S., Overton, L., Pal, A. K., Pal, S., Palmer, L., Pandit, A., Pelletier, E., Preston, R., Quetier, F., Raghuvanshi, S., Ragiba, M., Rambo, T., Reardon, M., Salanoubat, M., Salzberg, S. L., Samain, S., Sasaki, T., Scarpelli, C., Segurens, B., Sharma, S., Sharma, T. R., Singh, A., Singh, H., Singh, N. K., Singh, P. K., Singhal, V., Spiegel, L., Srivastava, S. K., Stum, D., Sureshbabu, K., Swain, S. C., Tallon, L., Tanyolac, B., Tsitrin, T., Tyagi, A. K., Utterback, T., Van Aken, S., Vij, S., Vuong, H., Vydianathan, R., Wang, A. H., Wang, W. M., Weaver, B., Weissenbach, J., White, O., Wincker, P., Wing, R. A., Wortman, J., Wu, J. Z., Yadav, M., Yu, Y., Yuan, Q. P., Zhu, W., Zismann, V., Zutavern, T.   +112 more
core   +1 more source

A child having rare Hereditary Multiple Exostosis with Covid-19 disease: A case study [PDF]

, 2022
: Hereditary Multiple Exostosis is a rare bone disease in pediatric age group. It is an autosomal dominant disorder, characterized by excessive bony overgrowth arising from lateral aspect of metaphysis of long bone, covered by a cartilaginous cap.
Hasnat, F, Rahman, Kazi Lutfar, Taher Anne, R, Tazia Tonny, R   +3 more
core   +2 more sources