Results 31 to 40 of about 2,559 (174)
Structural Features of Glypicans and their Impact on Wnt Signaling in Cancer. [PDF]
Proteoglycan ResABSTRACT Glypicans (GPCs) are a family of cell surface proteoglycans involved in multiple signaling pathways that regulate cell fate and proliferation. They share a characteristic structure composed of a core protein with two or more heparan sulfate chains and a glycosyl‐phosphatidylinositol anchor that attaches them to the cell membrane.
Tsao HE, Ho M.
europepmc +2 more sources
Enterovirus 71 uses cell surface heparan sulfate glycosaminoglycan as an attachment receptor [PDF]
, 2013 Enterovirus 71 (EV-71) infections are usually associated with mild hand, foot, and mouth disease in young children but have been reported to cause severe neurological complications with high mortality rates.
Chan, Yoke Fun +3 more
core +1 more source
Respiratory Research, 2021 Background Endothelial glycocalyx loss is integral to increased pulmonary vascular permeability in sepsis-related acute lung injury. Protectin conjugates in tissue regeneration 1 (PCTR1) is a novel macrophage-derived lipid mediator exhibiting potential ...
Xin-Yang Wang +9 more
doaj +1 more source
Filling the Gaps to Solve the Extensin Puzzle [PDF]
, 2018 Extensins (EXTs) are highly repetitive plant O-glycoproteins that require several post-translational modifications (PTMs) to become functional in plant cell walls.
Borassi, Cecilia +6 more
core +1 more source
Identification of the genes chemosensitizing hepatocellular carcinoma cells to interferon-α/5-fluorouracil and their clinical significance. [PDF]
PLoS ONE, 2013 The incidence of advanced hepatocellular carcinoma (HCC) is increasing worldwide, and its prognosis is extremely poor. Interferon-alpha (IFN-α)/5-fluorouracil (5-FU) therapy is reportedly effective in some HCC patients.
Tomohiko Sakabe +10 more
doaj +1 more source
Finding New Cell Wall Regulatory Genes in Populus trichocarpa Using Multiple Lines of Evidence. [PDF]
, 2019 Understanding the regulatory network controlling cell wall biosynthesis is of great interest in Populus trichocarpa, both because of its status as a model woody perennial and its importance for lignocellulosic products.
Chen, Jin-Gui +23 more
core +3 more sources
The FASEB Journal, 2021 Heparan Sulfate ProteoGlycans (HSPGs) are essential components of cells’ glycocalyx and Extracellular Matrix (ECM), which play key roles in cell physiology and in pathological scenarios. By binding to multiple biological ligands, via HS glycosaminoglycan (GAG) chains, HSPGs modulate cancer cells’ interaction with ECM and signalling networks, ultimately
Catarina Marques +6 more
openaire +1 more source
Antiproliferative effect of D-glucuronyl C5-epimerase in human breast cancer cells [PDF]
, 2010 Background D-glucuronyl C5-epimerase (GLCE) is one of the key enzymes in the biosynthesis of heparansulfate proteoglycans. Down-regulation of GLCE expression in human breast tumours suggests a possible involvement of the gene in carcinogenesis.
Tatiana Y Prudnikova +6 more
core +2 more sources
Genome-wide admixture and association study of subclinical atherosclerosis in the Women's Interagency HIV Study (WIHS). [PDF]
PLoS ONE, 2017 Cardiovascular disease (CVD) is a major comorbidity among HIV-infected individuals. Common carotid artery intima-media thickness (cCIMT) is a valid and reliable subclinical measure of atherosclerosis and is known to predict CVD.
Aditi Shendre +17 more
doaj +1 more source