Results 51 to 60 of about 2,559 (174)

Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. [PDF]

, 2019
Hepcidin is a liver-derived peptide hormone that controls systemic iron homeostasis. Its expression is regulated by the bone morphogenetic protein 6 (BMP6)/SMAD1/5/8 pathway and by the proinflammatory cytokine interleukin 6 (IL6).
Anower-E-Khuda, Ferdous, Arosio, Paolo, Asperti, Michela, Denardo, Andrea, Esko, Jeffrey D, Gordts, Philip LSM, Gryzik, Magdalena, Poli, Maura, Ruzzenenti, Paola   +8 more
core  

MO053: Are Renal Prognostic Markers Different in Patients with Exostosin 1/2 Positive or Negative Membranous Lupus Nephritis? A Single Center Experience in Turkey

Nephrology Dialysis Transplantation, 2022
Abstract BACKGROUND AND AIMS Recently, prognostic importance of antibodies in primary membranous nephropathy is well defined. However, knowledge about antibodies related to disease activity in membranous lupus nephritis (MLN) is limited. Exostosin1 and exostosin2 (EXT1/2) are novel antibodies detected
Zeynep Ebru Eser, Kenan Turgutalp, Yasemin Karabulut, Esra Akcali, Emre Cagatay Kose, Ebru Ballı, Simge Bardak, Serap Demir, Ahmet Kıykım   +8 more
openaire   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Transcriptomics in Venous Leg Ulcers (VLU): A Systematic Review

Wound Repair and Regeneration, Volume 34, Issue 2, March/April 2026.
ABSTRACT Venous leg ulcers (VLUs) are chronic wounds in the lower limbs that cause significant morbidity. The underlying biology underpinning non‐healing in VLUs is still poorly understood and differences in transcriptomic profiles may help elucidate biological pathways involved in wound chronicity.
Chien Lin Soh, Kia Hau Matthew Tan, Alun Huw Davies, Sarah Onida   +3 more
wiley   +1 more source

Abnormal sodium and water homeostasis in mice with defective heparan sulfate polymerization.

PLoS ONE, 2019
Glycosaminoglycans in the skin interstitium and endothelial surface layer have been shown to be involved in local sodium accumulation without commensurate water retention. Dysfunction of heparan sulfate glycosaminoglycans may therefore disrupt sodium and
Rik H G Olde Engberink, Judith de Vos, Angela van Weert, Yahua Zhang, Naomi van Vlies, Bert-Jan H van den Born, Jens M Titze, Ed van Bavel, Liffert Vogt   +8 more
doaj   +1 more source

A child having rare Hereditary Multiple Exostosis with Covid-19 disease: A case study [PDF]

, 2022
: Hereditary Multiple Exostosis is a rare bone disease in pediatric age group. It is an autosomal dominant disorder, characterized by excessive bony overgrowth arising from lateral aspect of metaphysis of long bone, covered by a cartilaginous cap.
Hasnat, F, Rahman, Kazi Lutfar, Taher Anne, R, Tazia Tonny, R   +3 more
core   +2 more sources

Clinical and Genetic Significance of Chromosomal Microarray Screening of Asymptomatic Newborns

Journal of Clinical Laboratory Analysis, Volume 40, Issue 3, February 2026.
Among 99 asymptomatic newborns with abnormal low‐resolution chromosomal microarray (LR‐CMA) screening, 70.7% harbored microduplication/microdeletions with syndromic implications. However, only a minority exhibited developmental concerns during early follow‐up, highlighting the need for cautious interpretation.
Naye Choi, Hwa Young Kim, Jung Min Ko
wiley   +1 more source

D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish [PDF]

, 2005
BACKGROUND: Heparan sulfate (HS) is an ubiquitous component of the extracellular matrix that binds and modulates the activity of growth factors, cytokines and proteases.
Farber, Steven A, Ghiselli, Giancarlo
core   +1 more source

The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications [PDF]

, 2005
Background: Rice is an important staple food and, with the smallest cereal genome, serves as a reference species for studies on the evolution of cereals and other grasses. Therefore, decoding its entire genome will be a prerequisite for applied and basic
Batra, K., Bera, J., Bhargava, A., Bharti, A. K., Buell, C. R., Cattolico, L., Choisne, N., Collura, K., Couloux, A., Currie, J., D'Hont, A., Dalal, V., de Vazeille, A. R., Demange, N., Dike, S., Dixit, A., Dixit, R., Du, C., Fadrosh, D., Feldblyum, T., Fraser, C., Fuks, G., Gaikwad, K., Gaur, A., Ghaz, I. A., Gupta, V., Haas, B., Hamilton, J., Hsiao, J., Iobst, S., Jiang, J. M., Jin, W. W., Johri, S., Jones, K. M., Kapur, A., Khurana, J. P., Khurana, P., Kim, H. R., Kim, M., Kramer, M., Kudrna, D., Kumar, D., Lewis, M., Lin, H. N., Linton, E., Liu, J., Matsumoto, T., McCombie, W. R., Mendiratta, S. D., Messing, J., Mizuno, H., Mohanty, A., Mohapatra, T., Mueller, C., Namiki, N., Nascimento, L., O'Shaughnessy, A., Orjeda, G., Ouyang, S., Overton, L., Pal, A. K., Pal, S., Palmer, L., Pandit, A., Pelletier, E., Preston, R., Quetier, F., Raghuvanshi, S., Ragiba, M., Rambo, T., Reardon, M., Salanoubat, M., Salzberg, S. L., Samain, S., Sasaki, T., Scarpelli, C., Segurens, B., Sharma, S., Sharma, T. R., Singh, A., Singh, H., Singh, N. K., Singh, P. K., Singhal, V., Spiegel, L., Srivastava, S. K., Stum, D., Sureshbabu, K., Swain, S. C., Tallon, L., Tanyolac, B., Tsitrin, T., Tyagi, A. K., Utterback, T., Van Aken, S., Vij, S., Vuong, H., Vydianathan, R., Wang, A. H., Wang, W. M., Weaver, B., Weissenbach, J., White, O., Wincker, P., Wing, R. A., Wortman, J., Wu, J. Z., Yadav, M., Yu, Y., Yuan, Q. P., Zhu, W., Zismann, V., Zutavern, T.   +112 more
core   +1 more source

Identification of genomic regions associated with partial resistance to Aphanomyces root rot in pea

The Plant Genome, Volume 18, Issue 4, December 2025.
Abstract Root rot caused by Aphanomyces euteiches is a major concern in pea (Pisum sativum L.). The lack of other effective control strategies makes crucial the development of resistant varieties. Although partial resistance has been reported, its quantitative inheritance, the association of resistance‐linked genomic regions with unfavorable agronomic ...
Sara Rodriguez‐Mena, Maria Carlota Vaz Patto, Susana Trindade Leitão, Diego Rubiales, Mario González   +4 more
wiley   +1 more source