Results 71 to 80 of about 2,559 (174)

#1267 Exostosin 1- and 2-positive membranous nephropathy in Chinese patients

Nephrology Dialysis Transplantation
Abstract Background and Aims The exostosin 1 and 2 (EXT1/2) complex was recently identified as a potential antigen associated with systemic autoimmunity in PLA2R-negative membranous nephropathy patients.
Guoqin Wang, Lijun Sun, Xiaoyi Xu, Nan Ye, Min Yang, Yanyan Wang, Wenrong Cheng, Zhirui Zhao, Xiaoyi Zhao, Yanqiu Geng, Feng Mei, Hong Cheng   +11 more
openaire   +1 more source

Single Molecule Force Spectroscopy at Cell Surfaces to Study Physical Properties of Heparan Sulfate Chains and Protein‐Heparan Sulfate Interactions

Proteoglycan Research, Volume 3, Issue 1, January-March 2025.
ABSTRACT Heparins and heparan sulfates (HS) are highly sulfated glycosaminoglycans that contribute to various physiological and pathophysiological processes such as coagulation, signal transduction, and extracellular matrix organization. In addition to its use as an anticoagulant, HS is therefore considered a promising compound for various biomedical ...
Alexandra Grossdorf, Tobias Obser, Yuanyuan Wang, Christian Gorzelanny   +3 more
wiley   +1 more source

BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors [PDF]

, 2012
BACKGROUND: As major regulators of normal chondrogenesis, the bone morphogenic protein (BMP) and transforming growth factor β (TGFB) signaling pathways may be involved in the development and progression of central chondrosarcoma.
Anne-Marie Cleton-Jansen, Brendy van den Akker, Burkhard Lehner, Judith VMG Bovée, Maayke van Ruler, Stephane Boeuf, Wiltrud Richter   +6 more
core   +1 more source

Alveolar Glycocalyces During Health and Critical Illness

Proteoglycan Research, Volume 3, Issue 1, January-March 2025.
ABSTRACT The alveolus, the functional unit of the lung, is comprised of closely approximated alveolar epithelial and endothelial cells, across which gas exchange occurs. This alveolar septum also includes two substantial, intraluminal extracellular matrices: the alveolar epithelial and endothelial glycocalyces.
Yimu Yang, Eric P. Schmidt
wiley   +1 more source

Development of a Proteomic Workflow for the Identification of Heparan Sulphate Proteoglycan‐Binding Substrates of ADAM17

PROTEOMICS, Volume 24, Issue 23-24, December 2024.
ABSTRACT Ectodomain shedding, which is the proteolytic release of transmembrane proteins from the cell surface, is crucial for cell‐to‐cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding of over 50 transmembrane proteins ranging from cytokines and growth factors, such as TNF and EGFR ligands, to ...
Matteo Calligaris, Donatella Pia Spanò, Maria Chiara Puccio, Stephan A. Müller, Simone Bonelli, Margot Lo Pinto, Giovanni Zito, Carl P. Blobel, Stefan F. Lichtenthaler, Linda Troeberg, Simone Dario Scilabra   +10 more
wiley   +1 more source

A STAT3 Gene Expression Signature in Gliomas is Associated with a Poor Prognosis [PDF]

, 2013
Gliomas frequently display constitutive activation of the transcription factor STAT3, a protein that is known to be able to mediate neoplastic transformation.
Alvarez, James V., Black, Peter McLaren, Chakladar, Abhijit, Chakravarti, Arnab, Frank, David A., Loeffler, Jay S, Mukherjee, Neelanjan, Robe, Pierre, Zhai, Gary   +8 more
core  

Case Report of the positive exostosin-1 without B-cell lymphoma-2 gene expression of giant cell tumor lesion in hereditary multiple exostosis

International Journal of Surgery Case Reports, 2016
The giant cell tumor, in which BCL-2 gene was expressed only in its malignant transformation, is a benign, primary skeletal neoplasm with variable biologic aggressiveness. The is of the giant cell tumor. A coexistence with hereditary multiple exostosis with expression of EXT-1 is very rare.
Eka Wiratnaya, I Gede, Aditya Gitapradita B., Nyoman Gede, Yudhi Setiawan, I G.N., Suyasa, I Ketut, Siki Kawiyana, I Ketut, Astawa, Putu   +5 more
openaire   +2 more sources

Unveiling the GT114 family: Structural characterization of A075L, a glycosyltransferase from Paramecium bursaria chlorella virus‐1 (PBCV‐1)

Protein Science, Volume 33, Issue 12, December 2024.
Abstract Protein A075L is a β‐xylosyltransferase that participates in producing the core of the N‐glycans found in VP54, the major viral capsid protein of Paramecium bursaria chlorella virus‐1 (PBCV‐1). In this study, we present an X‐ray crystallographic analysis of the apo form of A075L, along with its complexes with the sugar donor and with a ...
Maria Elena Laugieri, Immacolata Speciale, Ana Gimeno, Sicheng Lin, Brock W. Byers, Ana Poveda, Reyes Núñez‐Franco, Idoia Iturrioz, María J. Moure, Gonzalo Jiménez‐Osés, Irene Russo‐Krauss, Anna Notaro, James L. Van Etten, Todd L. Lowary, Jesús Jimenez‐Barbero, Cristina De Castro, Michela Tonetti, Adriana L. Rojas   +17 more
wiley   +1 more source

Biology of bone sarcomas and new therapeutic developments [PDF]

, 2017
Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities.
Brown, H.K., Gouin, F., Heymann, D., Heymann, M.-F., Schiavone, K.   +4 more
core   +1 more source

Heparin and heparan sulfate—The essence of sequence

Proteoglycan Research, Volume 2, Issue 4, October-December 2024.
Abstract Heparin, discovered as an anticoagulant more than 100 years ago, is composed of the same structural units as heparan sulfate, and their biosynthesis in the Golgi compartment is carried out by the same families of enzymes. However, while heparin is restricted to mast cells, heparan sulfate is widely distributed and is found at the cell surface ...
Lena Kjellén, Ulf Lindahl
wiley   +1 more source