Results 81 to 90 of about 2,559 (174)

Hereditary multiple exostoses: an educational review

Insights into Imaging
Hereditary multiple exostoses (HME), an autosomal dominant disorder with an incidence of 1:50,000 to 1:100,000, is characterised by the formation of multiple osteochondromas arising from the metaphyses of long and flat bones.
Alvaro Rueda-de-Eusebio, Sara Gomez-Pena, María José Moreno-Casado, Gloria Marquina, Juan Arrazola, Ana María Crespo-Rodríguez   +5 more
doaj   +1 more source

Identification of glycosyltransferases mediating 2‐O‐arabinopyranosyl and 2‐O‐galactosyl substitutions of glucuronosyl side chains of xylan

The Plant Journal, Volume 120, Issue 1, Page 234-252, October 2024.
SUMMARY Xylan is one of the major hemicelluloses in plant cell walls and its xylosyl backbone is often decorated at O‐2 with glucuronic acid (GlcA) and/or methylglucuronic acid (MeGlcA) residues. The GlcA/MeGlcA side chains may be further substituted with 2‐O‐arabinopyranose (Arap) or 2‐O‐galactopyranose (Gal) residues in some plant species, but the ...
Ruiqin Zhong, Dayong Zhou, Dennis R. Phillips, Earle R. Adams, Lirong Chen, John P. Rose, Bi‐Cheng Wang, Zheng‐Hua Ye   +7 more
wiley   +1 more source

A biological guide to glycosaminoglycans: current perspectives and pending questions

The FEBS Journal, Volume 291, Issue 15, Page 3331-3366, August 2024.
Mammalian glycosaminoglycans, except hyaluronan, are sulfated polysaccharides that are covalently attached to core proteins to form proteoglycans. They contribute to the organization of the extracellular matrix and are displayed at the cell surface where they regulate the availability and activity of cytokines and growth factors and cell signaling ...
Sylvie Ricard‐Blum, Romain R. Vivès, Liliana Schaefer, Martin Götte, Rosetta Merline, Alberto Passi, Paraskevi Heldin, Ana Magalhães, Celso A. Reis, Spyros S. Skandalis, Nikos K. Karamanos, Serge Perez, Dragana Nikitovic   +12 more
wiley   +1 more source

Islet regeneration protein Reg3g promotes macrophage clearance of β cell-derived dysfunctional mitochondria-rich vesicles to mitigate T2DM

Redox Biology
Under metabolic stress in type 2 diabetes mellitus (T2DM), β cells accumulate damaged mitochondria, and proinflammatory macrophages infiltrate pancreatic islets.
Senlin Li, Mengheng Wang, Hong Zhou, Jia Liu, Mengxuan Wang, Huimin Yuan, Mengzhu Zheng, Xin Li, Xiangling Zhu, Ming Xiang   +9 more
doaj   +1 more source

Polysaccharide-synthesizing Glycosyltransferases and Carbohydrate Binding Modules: the case of Starch Synthase III [PDF]

, 2013
Glycosyltransferases (GTs) are a ubiquitous group of enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.
Busi, María Victoria, Gomez Casati, Diego Fabian, Martín, Mariana   +2 more
core   +1 more source

A novel role of exostosin glycosyltransferase 2 (EXT2) in glioblastoma cell metabolism, radiosensitivity and ferroptosis

Cell Death & Differentiation
Abstract Glioblastoma (GBM) employs various strategies to resist therapy, resulting in poor patient survival. A key aspect of its survival mechanisms lies in metabolic regulation, maintaining rapid growth and evading cell death. Recent studies revealed the connection between therapy resistance and ferroptosis, a lipid peroxidation-dependent ...
Rocío Matesanz-Sánchez, Mirko Peitzsch, Inga Lange, Jovan Mircetic, Michael Seifert, Nils Cordes, Anne Vehlow   +6 more
openaire   +4 more sources

EXT1 as an Independent Prognostic Biomarker in Breast Cancer: Its Correlation with Immune Infiltration and Clinicopathological Parameters

Immuno
Exostosin 1 (EXT1) encodes a type II transmembrane glycosyltransferase residing in the endoplasmic reticulum and plays an essential role in the elongation of heparan sulfate chain biosynthesis. Additionally, EXT1 may act as an oncogene that could promote
Amira Hossny, Hatem A. F. M. Hassan, Sherif Ashraf Fahmy, Hazem Abdelazim, Mahmoud Mohamed Kamel, Ahmed H. Osman, Sherif Abdelaziz Ibrahim   +6 more
doaj   +1 more source

Genetic architecture of body size in mammals [PDF]

, 2012
Much of the heritability for human stature is caused by mutations of small-to-medium effect.
Goddard, Michael E., Kemper, Kathryn E., Visscher, Peter M.   +2 more
core   +1 more source

Genetic Fingerprint Concerned with Lymphatic Metastasis of Human Lung Squamous Cancer [PDF]

, 2009
Background and objective With the most recent introduction of microarray technology to biology, it becomes possible to perform comprehensive analysis of gene expression in cancer cell. In this study the laser microdissection technique and cDNA microarray
Li CHEN, Li LI, Liangbin LI, Mei WANG, Mingjian GE, Qingchen WU, Xiaolong ZHAO, Zhiming QIN   +7 more
core  

The significance of anti-PLA2R antibody in the diagnosis and treatment of primary membranous nephropathy

Linchuang shenzangbing zazhi, 2019
Primary membranous nephropathy(PMN) is a glomerulus-specific autoimmune disorder mainly caused by challenge of autoantibodies against the recently discovered antigens located on podocytes, such as the M-type phospholipase A2 receptor(PLA2R), the ...
XU Dong-mei, LIU Yi-peng
doaj