Results 221 to 230 of about 20,276 (258)

Pseudomonas exotoxin — Immunotoxins

1988
Monoclonal antibodies can be coupled with PE to make very potent ITs. Two of these ITs (PE-HB21 and OVB-3-PE) have been shown to have antitumor activity in a nude mouse model of ovarian cancer. PE ITs are at least 10-fold more active than the corresponding RTA IT.
D J, FitzGerald, M C, Willingham, I, Pastan   +2 more
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Bacterial exotoxins

The Pediatric Infectious Disease Journal, 1989
Article de synthese suyr la biochimie des exotoxines bacteriennes: classification, structure ...
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Septic Cardiomyopathy and Bacterial Exotoxins

Critical Care Medicine, 2018
Septic cardiopathy and bacterial exotoxins (letter)
Monticelli, Jacopo, Di Bella, Stefano, Di Masi, Alessandra, Zennaro, Cristina, Tonon, Federica, Luzzati, Roberto   +5 more
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Exotoxins of Pseudomonas aeruginosa. II. Concentration, Purification, and Characterization of Exotoxin A

Journal of Infectious Diseases, 1973
Exotoxin A of Pseudomonas aeruginosa (PA-103) could be concentrated readily by precipitation with zinc acetate and ammonium sulfate. The toxin was purified by column chromatography with use of DEAE-cellulose and Sephadex G-200. The final product contained about 8,000 mouse LD,,0/mg of protein.
P V, Liu, S, Yoshii, H, Hsieh
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6.10 Bacterial Exotoxins

1998
Publisher Summary This chapter discusses bacterial exotoxins. Disruption of normal cell function is the critical outcome in bacterial diseases. Bacteria produce a variety of virulence factors for this purpose and the arsenal of most pathogenic bacteria includes exotoxins. Exotoxins subvert, alter, or destroy host cell functions ultimately, leading to
Mahtab Moayeri, Rodney A. Welch
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Exotoxin in malaria infection (Plasmodium berghei)

Experientia, 1967
Swiss Mause, die unbehandelt eine Infektion mitPl. berghei niemals uberleben, wurden mit Serum von frisch infizierten Tieren (12. Infektionstag) immunisiert und anschliessend infiziert. Obgleich sich danach in allen Fallen eine schwere Parasitamie entwickelte, heilten 44% derjenigen Tiere nach dem 35.
S, Jerusalem, D, Bruchhausen
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Pseudomonas aeruginosaExotoxin A

New England Journal of Medicine, 1980
Pseudomonas aeruginosa is an opportunistic pathogen that causes more than 100,000 infections in the United States each year. Pseudomonas infections are associated with considerable morbidity and mortality despite the use of modern antibiotics.1 Recognition of the limitations of existing therapy for pseudomonas disease has stimulated renewed interest in
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Kawasaki Disease and Staphylococcal Exotoxins

Archives of Dermatology, 1980
To the Editor.— In their recent report of a possible case of Kawasaki disease, Schlossberg et al 1 discuss the possibility that a staphylococcal exotoxin, found in the patient's vaginal discharge, may have been responsible for her symptoms. The pyrogenic exotoxin that they isolated, however, lacked exfoliative activity in the rabbit and mouse.
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Redirecting Pseudomonas exotoxin.

Seminars in cell biology, 1992
Pseudomonas exotoxin (PE) is a three-domain bacterial toxin that kills mammalian cells by gaining entry to the cytosol and inactivating protein synthesis. The pathway of toxin entry includes binding to a surface receptor, internalization via coated pits and endosomes, proteolytic processing, reduction of disulfide bonds and finally the translocation of
D, FitzGerald, I, Pastan
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