Results 21 to 30 of about 109,579 (253)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
IAPSO Standard Seawater: definition of the uncertainty in the calibration procedure, and stability of recent batches [PDF]
, 2007 Standard seawater (SSW) has been employed by oceanographers as a reference material in the determinationof salinity for over a century. In all that time, this is the first study to determine the uncertaintyof the SSW manufacturing process.
Nigel Higgs +8 more
core +1 more source
Evaluation of expanded uncertainties in luminous intensity and illuminance calibrations
Applied Optics, 2008 Detector-based calibrating methods and expressions for calculation of photometric uncertainties related to uncertainties in the calibrations of luminous intensity of a light source, illuminance responsivity of a photometer head, and calibration factors of an illuminance meter are discussed.
openaire +3 more sources
Examples of the expanded uncertainty evaluation based on the kurtosis method
, 2022 Examples of the expanded uncertainty evaluation based on the kurtosis ...
Zakharov, I. P., Botsiura, O. A.
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A Proposed Estimation of the Expanded Uncertainty of Charpy Impact Testers
Asian Journal of Applied Sciences, 2020 Uncertainty estimation is one of the very delicate tasks in the field of measurements. For the purpose of calibration of Charpy impact testing machines, it is necessary to evaluate and identify the expanded uncertainty. Factors affecting the uncertainty estimations are; the uncertainty of reference force and length measuring devices and its long-term ...
null A. Abu-Sinna, Saher R. Hassan
openaire +2 more sources
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source