Results 91 to 100 of about 1,860,920 (244)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Anuario Colombiano de Historia Social y de la Cultura, 1999 Este artículo resalta las características del mercado local de tierras a partir del proceso de adjudicación de baldíos, precisando el dinamismo empresarial en torno a la explotación minera y la expansión de la caficultura durante la llamada colonización ...
Renzo Ramírez Bacca
doaj +2 more sources
Mirai, 2019 Este estudio utiliza material inédito proveniente de los Archivos del Ministerio de Asuntos Exteriores japonés para sumergirse en la vida y, sobre todo, la muerte de un comerciante japonés, un individuo desconocido, casi anónimo, que emigró a las islas ...
Gonzalo San Emeterio Cabañes
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Indicadores del nivel de globalización en las regiones de México: caso, la industria alimentaria [PDF]
, 2015 La globalización es un fenómeno inherente al desarrollo capitalista, con nuevos elementos de manifestación en las últimas décadas. Así, este trabajo trata sobre el análisis de la globalización en su proceso Expansión-Integración y sus efectos en las ...
Ibarvo Urista, Virginia +2 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The interplay between boundary spanning activities and social cohesion in new product development teams [PDF]
, 2017 Team boundary spanning represents a team’s actions to establish links and manage interactions with individuals and groups external to the team with the purpose of coordinating activities and accessing information, resources and political support ...
Carbonell, Pilar +2 more
core
La expansión urbana del municipio de Tlajomulco de Zuñiga [PDF]
, 2009 A comienzos de la segunda mitad del siglo pasado, las ciudades centrales del México comenzaron a sufrir un proceso constante de crecimiento e integración de sus comunidades aledañas, proceso que se ha definido como metropolización.
Colunga Flores, Leopoldo Alejandro
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source