Results 41 to 50 of about 1,414,501 (231)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Mirai, 2019 Este estudio utiliza material inédito proveniente de los Archivos del Ministerio de Asuntos Exteriores japonés para sumergirse en la vida y, sobre todo, la muerte de un comerciante japonés, un individuo desconocido, casi anónimo, que emigró a las islas ...
Gonzalo San Emeterio Cabañes
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
La afiliación sindical en la crisis Estructura, evolución y trayectorias
Sociología del Trabajo, 2016 La crisis económica y la desregulación del mercado de trabajo han transformado radicalmente el modelo de relaciones laborales, debilitado a sus actores e institucio-nes y generado un dramático incremento de la desigualdad social.
Pere Beneyto +3 more
doaj +2 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Praxis EducativaEste artículo tiene por objeto el análisis de las relaciones entre la configuración y la expansión del nivel secundario, y de la formación docente inicial para ese nivel en Tierra del Fuego A.e.I.A.S, (1991-2006). Se trata del estudio comparativo de dos
Ricardo Luis Paez +1 more
doaj +4 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Plan de expansión comercial para Osaka Spa en Baños de Agua Santa
, 2018 1. El Problema. --2. Marco Teórico. --3. Marco Metodológico. --4. Análisis e Interpretación de Resultados. --5. Propuesta. --6. Conclusiones y Recomendaciones.El objetivo del proyecto de investigación se sustenta en diseñar un plan de expansión comercial
Mayorga Bonilla, Daniela Melissa
core +1 more source