Results 61 to 70 of about 1,235,704 (198)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Un sastre a la medida: breves comentarios para el desarrollo de proyectos built-to-suit
Derecho & Sociedad, 2020 En este artículo se plantea una primera aproximación a los proyectos built to suit (BTS) desde un punto de vista económico y legal, tanto para facilitar a los operadores jurídicos su entendimiento como para dar sentido y pautas claras respecto de su ...
Vega Mere, Yuri, Muñoz Sivana, Anthony
doaj
Consideraciones sobre la hidrogeología oficial
Boletín Geológico, 1953 Este informe destaca la importancia del agua subterránea como elemento imprescindible en las actividades humanas modernas. Se resumen las labores hechas al respecto en Colombia, con miras hacia la expansión en favor del progreso nacional, y la ...
Wolfgang Diezemann, Jaime López Casas
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
As políticas brasileiras para a Educação Superior a Distância: Desafios da expansão
Revista Historia de la Educación Latinoamericana, 2019 El texto con foco en las políticas nacionales para la educación superior a distancia (EaD) tiene como objetivo analizar la trayectoria de las políticas para esta modalidad y reflexionar acerca de los desafíos que su crecimiento viene colocando para ...
Celia María Haas +2 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Mirai, 2019 Este estudio utiliza material inédito proveniente de los Archivos del Ministerio de Asuntos Exteriores japonés para sumergirse en la vida y, sobre todo, la muerte de un comerciante japonés, un individuo desconocido, casi anónimo, que emigró a las islas ...
Gonzalo San Emeterio Cabañes
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source