Results 81 to 90 of about 2,429,010 (293)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Animal, 2011 Dairy herd size is expected to increase in many European countries, given the recent policy changes within the European Union. Managing more cows may have implications for herd performance in the post-quota era.
J.G. Jago, D.P. Berry
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Frontiers in Human NeuroscienceThe evolutionary adaptation of the left inferior frontal gyrus is considered a crucial neural specialization supporting the emergence of human language.
Jinyi Zhang +5 more
doaj +1 more source
EUROPEAN NEIGHBOURHOOD POLICY: EVOLUTION AND PRIORITIES [PDF]
Economica, 2019 The article analyses the evolution and changes made in the European Neighbourhood Policy (ENP) since its launch in 2004. It shows that the change of the socio-economic situation and a series of conflicts in the neighbourhood of the European Union ...
Natalia LOBANOV
doaj
Polish Political Science Yearbook, 2014 The paper discusses the problem of difficult conflicts, whose dynamics is characterised by intensifi cation of factors influencing the course of a conflict, and conflicts which are considerably difficult to resolve. Among many conflicts of high intensity and escalation it is legitimate to identify a specific group of conflicts which can be viewed in a ...
openaire +1 more source
THE EXPANSION OF CHRISTIANITY [PDF]
The Journal of Theological Studies, 1904 n ...
openaire +2 more sources