Results 71 to 80 of about 4,612,820 (291)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Biomass expansion factor and root-to-shoot ratio for Pinus in Brazil

open access: yesCarbon Balance and Management, 2011
The Biomass Expansion Factor (BEF) and the Root-to-Shoot Ratio (R) are variables used to quantify carbon stock in forests. They are often considered as constant or species/area specific values in most studies.
da Silva Fernando   +2 more
doaj   +1 more source

Auxetic incisions with alternating slit shapes: a promising technique for enhancing synthetic skin grafts expansion

open access: yesMaterials Research Express, 2023
Split thickness skin grafts are widely used in treating burn injuries. To date, with limited availability of donor skin and minimal expansions offered by conventional skin grafting, it is challenging to cover large and severe burns.
Vivek Gupta, Arnab Chanda
doaj   +1 more source

Pressure Drop of Two-Phase Flow Through Horizontal Channel with Smooth Expansion [PDF]

open access: yes, 2012
Industrial systems at where gas-liquid flow is extensively used generally have complex geometries including singularities like expansion, contraction, bends and orifices.
Eskin, Nurdil, Deniz, Emrah
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Uniform Asymptotic Expansion of Likelihood Ratio for Markov Dependent Observations

open access: yes
Likelihood ratio, Markov process, asymptotic expansion, functional limit theorem, sequential probability ratio test,
Andrei Novikov
core   +1 more source

Subgroup analyses relating to the diagnostic odds ratio (DOR) of first-pass CTA for hematoma expansion.

open access: yes, 2014
Subgroup analyses relating to the diagnostic odds ratio (DOR) of first-pass CTA for hematoma expansion.
Ming Gu (115606)   +4 more
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

open access: yesFEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park   +8 more
wiley   +1 more source

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