Results 211 to 220 of about 3,596,779 (304)

Editorial Note: Gender expectations, socioeconomic inequalities and definitions of career success: A qualitative study with university students. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Patients' expectations, willingness to use, and willingness to pay for telepharmacy in rural and urban community pharmacies. [PDF]

Explor Res Clin Soc Pharm
Ilma DL, Utami VVFR, Sholihat NK.
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Early technology review during prototype development and at proof of concept: the case for developing a sequential versus a single-stage approach to early evidence development for health technologies. [PDF]

Int J Technol Assess Health Care
Levin L, McDonough RS, Cheatle M, Kaafarani H, Korjian S, Kuntz RE.   +5 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Optimizing expectations in an internet- and mobile-based intervention for depression: study protocol for a randomized factorial trial. [PDF]

Trials
Schaeuffele C, Heinrich M, Haering S, Kampisiou C, Bellu L, Burchert S, Puetz M, Wabiszczewicz J, Wilhelm M, Zagorscak P, Rief W, Knaevelsrud C.   +11 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

How to Involve Families in Hospital Care: Development, Content Validation, and Feasibility of a Concise Family Assessment Framework. [PDF]

Scand J Caring Sci
Woldring JM, Paans W, Gans ROB, Luttik ML.   +3 more
europepmc   +1 more source