Results 61 to 70 of about 1,084,741 (275)
Nature CommunicationsThe dynamics of proteins are crucial for understanding their mechanisms. However, computationally predicting protein dynamic information has proven challenging.
Xintao Song +6 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Genome BiologyThe rapid advancements in spatially resolved transcriptomics (SRT) enable the characterization of gene expressions while preserving spatial information. However, high dropout rates and noise hinder accurate spatial domain identification for understanding
Shuli Sun +3 more
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On sequences of expected maxima and expected ranges [PDF]
Journal of Applied Probability, 2017 Abstract We investigate conditions in order to decide whether a given sequence of real numbers represents expected maxima or expected ranges. The main result provides a novel necessary and sufficient condition, relating an expected maxima sequence to a translation of a Bernstein function through its Lévy–Khintchine representation.
openaire +4 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Some Human Dimensions of Understanding Flood Risk Management
HydrologyFlood risk management involves managing the consequences of flooding as well at its hazard characteristics. This means attending to the human effects of floods and flood risk reduction. These effects are many and varied and are often poorly understood by
Edmund C. Penning-Rowsell
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FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Complexity and Innovation. Why Beneficial Effects of Innovation Highly Depend [PDF]
Журнал институциональных исследований, 2019 Mainstream economics and everyday consciousness tend to declare any change an “innovation”. Innovation thus appears as a black box. It seems to lack a criterion to distinguish a counterproductive change – e.g., a dynamic perceived by agents as over ...
Wolfram Elsner
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source