Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Exchange Rate Exposure of Sectoral Returns and Volatilities: Evidence from Japanese Industrial Sectors [PDF]
Most studies of exchange rate exposure of stock returns do not address three relevant aspects simultaneously. They are, namely: sensitivity of stock returns to exchange rate changes; sensitivity of volatility of stock returns to volatility of changes in ...
Prabhath Jayasinghe, Albert K. Tsui
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Lead Exposure and Prevention Advisory Committee (LEPAC) : 2020 annual report to U.S. Department of Health and Human Services [PDF]
The objective of the Lead Exposure and Prevention Advisory Committee (LEPAC) is to review research andFederal programs and services related to lead poisoning and to identify effective services and best practices for addressing and preventing lead ...
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Evaluation of the expected doses of fire brigades at the Chornobyl Exclusion Zone in April 2015
Ядерна фізика та енергетика, 2015 Assessment is given of area and behavior of large wildfire in the Chornobyl Exclusion Zone (ChEZ) which has been burning during April 27 - 29, 2015.
V. A. Kashparov +4 more
doaj
EFSA Journal, 2015 The product L‐valine is a feed additive produced by fermentation with a genetically modified strain of Escherichia coli (NITE BP‐01755). Neither the production strain E. coli NITE BP‐01755 nor its recombinant DNA was detected in the final product.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Mapping efforts to identify populations at higher risk of lead exposure: HUD perspective [PDF]
HUD-mapping-efforts-populations-high-risk-lead-exposure-Dec-LEPAC-508 ...
core
Environmental Exposure, Biomonitoring and Exposure Assessment
Environmental exposure plays an important role in the development of diseases. However, individuals are exposed to complex mixtures of substances (e.g., chemicals, pollution, and diet) that change throughout a person’s life.
core +1 more source