Results 71 to 80 of about 5,035,408 (306)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Lead Exposure and Prevention Advisory Committee (LEPAC) : 2021 annual report to U.S. Department of Health and Human Services [PDF]

The objective of the Lead Exposure and Prevention Advisory Committee (LEPAC) is to review research and federal programs and services related to lead poisoning and to identify effective services and best practices for addressing and preventing lead ...

core  

Respiratory symptoms and lung function in relation to wood dust and monoterpene exposure in the wood pellet industry

Upsala Journal of Medical Sciences, 2017
Introduction: Wood pellets are used as a source of renewable energy for heating purposes. Common exposures are wood dust and monoterpenes, which are known to be hazardous for the airways.
Håkan Löfstedt, Katja Hagström, Ing-Liss Bryngelsson, Mats Holmström, Anna Rask-Andersen   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Lead Exposure and Prevention Advisory Committee (LEPAC) : 2022 annual report to U.S. Department of Health and Human Services [PDF]

The objective of the Lead Exposure and Prevention Advisory Committee (LEPAC) is to review research and federal programs and services related to lead poisoning and to identify effective services and best practices for addressing and preventing lead ...

core  

Developing a general population job-exposure matrix in the absence of sufficient exposure monitoring data. [PDF]

, 2011
In New Zealand, there is a need for a comprehensive and accessible database with national occupational exposure information, such as a general population job-exposure matrix (GPJEM).
McLean, Dave J, 't Mannetje, Andrea M, Fevotte, Joelle, Kauppinen, Timo, Eng, Amanda J, Kromhout, Hans, Pearce, Neil E   +6 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Interest Rate Exposure of Nonfinancial Corporations [PDF]

Many interest rates are as volatile as exchange rates and thus represent an equally important source of risk for corporations. While this is true not only for financial institutions, but for other corporations as well, little is known about the interest ...
Sohnke M. Bartram
core  

A study protocol testing pre-exposure dose and compound pre-exposure on the mechanisms of latent inhibition of dental fear

BMC Psychology
Background Dental stimuli can evoke fear after being paired - or conditioned - with aversive outcomes (e.g., pain). Pre-exposing the stimuli before conditioning can impair dental fear learning via a phenomenon known as latent inhibition.
Andrew L. Geers, Laura D. Seligman, Keenan A. Pituch, Ben Colagiuri, Hilary A. Marusak, Christine A. Rabinak, Natalie Turner, Sena L. Al-Ado, Michael Nedley   +8 more
doaj   +1 more source

Determination of acceptable margins of exposure (MoE) for NAM-based skin sensitisation risk assessment

NAM Journal
Skin sensitisation safety decisions for consumer goods predominantly use approaches such as Quantitative Risk Assessment (QRA) to judge whether a dermal exposure is low risk by comparing a point of departure (PoD) against an expected consumer exposure ...
Joe Reynolds, Maja Aleksic, Nicola Gilmour, Georgia Reynolds   +3 more
doaj   +1 more source