Results 101 to 110 of about 6,405,842 (302)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Why Do People Pay Taxes? Prospect Theory Versus Expected Utility Theory [PDF]
Tax evasion analysis is typically based on an expected utility theory (EUT) framework. However, this leads to several qualitative and quantitative puzzles.
Sanjit Dhami, Ali al-Nowaihi
core
Influence of Expected Loan Loss on Operational Performance of Commercial Banks in Kenya
Journal of Accounting and Finance in Emerging EconomiesPurpose: The main objective of this study was to examine influence of credit risk stress testing on operational performance of commercial Kenya. The theoretical framework was based on credit risk theory.
Nyanumba Nyaundi Joel +2 more
doaj +1 more source
Study on seismic risk assessment model of water supply systems in mainland China [PDF]
Natural Hazards and Earth System SciencesUsing the peak ground acceleration (PGA) under four exceedance probabilities calculated via a probabilistic seismic hazard analysis method for China, the probability density function of PGA was obtained by fitting with the Cornell seismic hazard ...
T. Yu +7 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Probability Distortion and Loss Aversion in Futures Hedging [PDF]
We analyze how the introduction of probability distortion and loss aversion in the standard hedging problem changes the optimal hedge ratio. Based on simulated cash and futures prices for soybeans, our results indicate that the optimal hedge changes ...
Pennings, Joost M.E. +2 more
core
Expected net present value, expected net future value, and the Ramsey rule [PDF]
, 2009 Weitzman (1998) showed that when future interest rates are uncertain, using the expected net present value implies a term structure of discount rates that is decreasing to the smallest possible interest rate.
GOLLIER, Christian
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Dynamic provisioning: a countercyclical tool for loan loss reserves [PDF]
In the wake of the financial crisis of 2007-2009, as various banking policymakers revisit loan loss provisioning rules, the Spanish approach of dynamic provisioning has garnered attention as a potential alternative to the current incurred loss approach ...
Andrew McKenna, Eliana Balla
core
Expected Annual Loss as a Global Metric for Seismic Performance Assessment of Existing Buildings
BuildingsThe assessment of seismic performance of existing buildings has traditionally focused on structural safety and damage limitation, often neglecting the explicit quantification of the associated economic consequences.
Roberto Nascimbene, Emanuele Brunesi
doaj +1 more source