Results 91 to 100 of about 1,764,628 (294)

Decision Uncertainty from Strict Preferences in Sequential Search Scenarios with Multiple Criteria

Mathematics
The standard expected utility model applied by economists and decision scientists assumes both that decision makers (DMs) are rational and that their information retrieval behavior and choices are determined by the observed and potential values of the ...
Debora Di Caprio, Yolanda Durán Durán, Francisco Javier Santos-Arteaga   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Filozofická reflexe omezené racionality (Philosophical Reflection of Bounded Rationality )

Ostium, 2017
Research of rationality represents area of interaction between philosophy and economics. Development of neuroscience and advances in scientific research lead to another common characteristic – gradual loss of competence to comment on results of ...
Michal Müller, Ondrej Močkor
doaj  

How to Model Lexical Priority

Ergo, An Open Access Journal of Philosophy
A moral requirement R1 is said to be lexically prior to a moral requirement R2 just in case we are morally obliged to uphold R1 at the expense of R2—no matter how many times R2 must be violated thereby. While lexical priority is a feature of many ethical
Martin Smith
doaj   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Convergence of optimal expected utility for a sequence of binomial models. [PDF]

Math Financ, 2021
Hubalek F, Schachermayer W.
europepmc   +1 more source

Facts, Norms and Expected Utility Functions [PDF]

In this paper we want to explore an argumentative pattern that provides a normative justification for expected utility functions grounded on empirical evidence, showing how it worked in three different episodes of their development.
David Teira, Pierre-Charles Pradier, Sophie Jallais   +2 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The Impact of the Expected Utility and Experienced Utility Gap on Electric Vehicle Repurchase Intention in Jiangsu, China

World Electric Vehicle Journal
The global automotive industry’ s rapid transformation has led to electric vehicles (EVs) capturing a significant market share as a sustainable transportation option.
Xiao Zheng, Jiaxin Huang, Mengzhe Wang, Wenbo Li   +3 more
doaj   +1 more source