Results 171 to 180 of about 2,911,222 (308)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Nonparametric Approach for Estimating the Effective Sample Size in Gaussian Approximation of Expected Value of Sample Information. [PDF]

Med Decis Making
Li L, Jalal H, Heath A.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The Value Relevance of Sentiment [PDF]

It is generally accepted that excessive exuberance or gloom in investor sentiment contributes to booms and crashes in share prices. However, views differ on the merits of active policy intervention due to gaps in our understanding of the transmission ...
Dunne, Peter, Forker, John, Zholos, Andrey   +2 more
core  

Gambling disorder is associated with reduced sensitivity to expected value during risky choice. [PDF]

J Behav Addict, 2020
Limbrick-Oldfield EH, Cherkasova MV, Kennedy D, Goshko CB, Griffin D, Barton JJS, Clark L.   +6 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

THE VALUE OF INFORMATION IN HERBICIDE DECISION MAKING FOR WEED CONTROL IN AUSTRALIAN WHEAT CROPS

Most weed control decisions are made with the benefit of some information about weather conditions and actual weed densities. This study is an investigation of the value of adjusting weed control decisions in response to these types of information. For a
Pannell, David J.
core  

Blunted sensitivity to expected value during risky decision making in individuals with problematic pornography use. [PDF]

J Behav Addict
Wang J, Qu S, Li R, Tang S, Li H.
europepmc   +1 more source

Immediate Versus Delayed Hip Arthroscopy for Femoroacetabular Impingement: An Expected Value Decision Analysis. [PDF]

J Am Acad Orthop Surg Glob Res Rev, 2020
Mehta MP, Hoffer-Hawlik MA, O'Connor M, Lynch TS.   +3 more
europepmc   +1 more source

Fat-Free Mass Index, Visceral Fat Level, and Muscle Mass Percentage Better Explain Deviations From the Expected Value of Aortic Pressure and Structural and Functional Arterial Properties Than Body Fat Indexes. [PDF]

Front Nutr, 2022
Gómez-García M, Torrado J, Pereira M, Bia D, Zócalo Y.   +4 more
europepmc   +1 more source