Results 71 to 80 of about 9,029,772 (294)

MODEL OF DETERMINING THE PEDESTRIANS’ DELAY IN THE CROSSING OF STREETS AND ROADS OUTSIDE THE PEDESTRIAN CROSSING [PDF]

Avtomobilʹnyj Transport (Harʹkov), 2017
The rational organization of the junction of the transport and pedestrian flows on the urban streets and intercity roads based on the criterion of traffic participant’s summary time consumption for overcoming the conflict area is substantiated.
P. Horbachov, А. Makarichev, A. Atamanyuk   +2 more
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

AN EVALUATION OF EXPECTED VALUE AND EXPECTED VALUE-VARIANCE CRITERIA IN ACHIEVING RISK EFFICIENCY IN CROP SELECTION [PDF]

This article evaluates the performance of expected value and expected value-variance criteria in achieving risk efficiency in crop selection. Results indicate that the expected returns criterion achieves risk efficiency in many situations because of ...
Reid, Donald W., Tew, Bernard V.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Cognitive abilities and superior decision making under risk: A protocol analysis and process model evaluation

Judgment and Decision Making, 2009
Individual differences in cognitive abilities and skills can predict normatively superior and logically consistent judgments and decisions. The current experiment investigates the processes that mediate individual differences in risky choices.
Edward T. Cokely, Colleen M. Kelley
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Two-Stage Bi-Objective Stochastic Models for Supplier Selection and Order Allocation Under Uncertainty

Systems
In supply chain management practices, supplier selection (SS) is a critical strategic planning activity that usually constitutes an ex ante decision made under uncertainty, whereas order allocation (OA) represents a subsequent operational decision ...
Lingzhen Zhang, Ke Wang
doaj   +1 more source

Calculating the Expected Value of Sample Information using Efficient Nested Monte Carlo: A Tutorial [PDF]

, 2018
Objective: The Expected Value of Sample Information (EVSI) quantifies the economic benefit of reducing uncertainty in a health economic model by collecting additional information.
Baio, Gianluca, Heath, Anna
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source