Results 121 to 130 of about 1,621,811 (255)

Radioiodine Therapy Unit as a "No-Care" Ward - A First Experience Report. [PDF]

open access: yesNuklearmedizin
Freesmeyer M   +6 more
europepmc   +1 more source

Implementation of a nursing strategy for self-transcendence in older adults: an experience report. [PDF]

open access: yesRev Bras Enferm, 2023
Ramírez JGM   +2 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Real-world treatment management in hereditary transthyretin amyloidosis - an experience report and proposal for therapy switch decision criteria. [PDF]

open access: yesNeurol Res Pract
Dieu DC   +9 more
europepmc   +1 more source

Interest Groups as an Alternative for Medical Education in Sleep Medicine: Experience Report at a Brazilian Medical School. [PDF]

open access: yesClocks Sleep, 2022
Pinto VLS   +7 more
europepmc   +1 more source

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