Results 161 to 170 of about 9,267,633 (320)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote +8 morewiley +1 more sourceAdaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch +16 morewiley +1 more sourcePatient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert +16 morewiley +1 more sourceData on the temporal changes in soil properties and microbiome composition after a jet-fuel contamination during the pot and field experiments
, 2022 И. Н. Семенков, Pavel V. Shelyakin, Daria D. Nikolaeva, Maria N. Tutukina, Anna Sharapova, Sergey Lednev, Yuliya V. Sarana, Mikhail S. Gelfand, П. П. Кречетов, Т. В. Королева +9 moreopenalex +1 more sourcePredictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman +17 morewiley +1 more sourceCharacterization and evaluation of tamarind (Tamarindus indica L.) germplasm: implications for tree improvement strategies
BMC Plant BiologyBackground Tamarind (Tamarindus indica L.; Fabaceae) a unique tree is valued not only for its fruits and timber but also for its shade, making it a popular avenue tree.A. K. Singh, Vikas Yadav, V. V. Appa Rao, Daya Shankar Mishra, Lalu Prasad Yadav, K. Gangadhara, Jagadish Rane, A. Sahil, Prakashbhai Ravat, P. Janani, Prashant Kaushik, Ali Khadivi, Yazgan Tunç +12 moredoaj +1 more sourceFeasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis +11 morewiley +1 more sourceInitial physics achievements of large helical device experiments [PDF]
, 1999 O. Motojima, H. Yamada, A. Komori, N. Ohyabu, K. Kawahata, O. Kaneko, S. Masuzaki, A. Ejiri, M. Emoto, H. Funaba, M. Goto, K. Ida, H. Idei, S. Inagaki, Noriyuki Inoue, S. Kado, S. Kubo, R. Kumazawa, T. Minami, J. Miyazawa, T. Morisaki, S. Morita, S. Murakami, S. Muto, T. Mutoh, Y. Nagayama, Y. Nakamura, H. Nakanishi, K. Narihara, K. Nishimura, N. Noda, T. Kobuchi, S. Ohdachi, Y. Oka, M. Osakabe, T. Ozaki, B. J. Peterson, A. Sagara, S. Sakakibara, R. Sakamoto, H. Sasao, M. Sasao, K. Sato, M. Sato, T. Seki, Τ. Shimozuma, M. Shoji, H. Suzuki, Y. Takeiri, K. Tanaka, K. Toi, T. Tokuzawa, K. Tsumori, K. Tsuzuki, I. Yamada, Satoshi Yamaguchi, M. Yokoyama, K.Y. Watanabe, T. Watari, Y. Hamada, K. Matsuoka, K Murai, Κ. Ohkubo, I. Ohtake, M. Okamoto, Shuichi Satoh, T. Satow, S. Sudo, S. Tanahashi, K. Yamazaki, Masami Fujiwara, A. Iiyoshi +71 moreopenalex +1 more source
