Results 31 to 40 of about 149 (146)

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

The WArP Experiment

Journal of Physics: Conference Series, 2010
Cryogenic noble liquid detectors are presently considered one of the best options for WIMP Dark Matter searches, especially when extensions to multi ton scale sensitive masses are foreseen. The WArP experiment is the first one that exploits the unique characteristics of liquid Argon to make a highly sensitive search for WIMP Dark Matter candidates.
R. Acciarri, M. Antonello, B. Baibussinov, P. Benetti, F. Calaprice, E. Calligarich, M. Cambiaghi, N. Canci, C. Cao, F. Carbonara, F. Cavanna, S. Centro, M. B. Ceolin, A. Chavarria, A. Cocco, F. D. Pompeo, FIORILLO, GIULIANA, C. Galbiati, L. Grandi, B. Loer, G. Mangano, A. Menegolli, G. Meng, C. Montanari, O. Palamara, L. Pandola, F. Pietropaolo, G. L. Raselli, M. Roncadelli, M. Rossella, C. Rubbia, R. Saldanha, E. Segreto, A. Szelc, S. Ventura, C. Vignoli   +35 more
openaire   +9 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

SOME EXPERIENCES WITH NEW EXPERIMENTS [PDF]

School Science and Mathematics, 1904
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openaire   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

The OPERA experiment

Nuclear and Particle Physics Proceedings, 2015
AbstractThe OPERA experiment was designed to study νμ→ντ oscillations in appearance mode using the CERN to Gran Sasso high energy neutrino beam. From 2008 to 2012, 19505 CNGS neutrino interactions were recorded in the OPERA detector. At the present status of the analysis, 4 ντ candidate events have been observed, establishing the oscillation mechanism ...
Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Bender, D., BERTOLIN, ALESSANDRO, Bozza, C., BRUGNERA, RICCARDO, Buonaura, A., Buontempo, S., Büttner, B., Chernyavsky, M., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Del Amo Sanchez, P., Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., DUSINI, STEFANO, Dzhatdoev, T., Ebert, J., Ereditato, A., Fini, R. A., Fukuda, T., Galati, G., GARFAGNINI, ALBERTO, Giacomelli, G., Göllnitz, C., Goldberg, J., Gornushkin, Y., Grella, G., Guler, M., Gustavino, C., Hagner, C., Hara, T., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kawada, J., Kim, J. H., Kim, S. H., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., KOSE, UMUT, Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., LONGHIN, ANDREA, Loverre, P., Malgin, A., Malenica, M., Mandrioli, G., Matsuo, T., Matveev, V., Mauri, N., MEDINACELI VILLEGAS, EDUARDO, Meregaglia, A., Mikado, S., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Okateva, N., Olshevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., RODA, MARCO, Rokujo, H., Roganova, T., Rosa, G., Ryazhskaya, O., Sato, O., Schembri, A., Shakiryanova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., SIRIGNANO, CHIARA, Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strauss, T., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., Zemskova, S., Zghiche, A.   +138 more
openaire   +5 more sources