Results 31 to 40 of about 5,187,758 (262)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Determination and Pharmacokinetics of Acetylcorynoline in Mouse Plasma by UPLC–MS/MS

International Journal of Analytical Chemistry
Acetylcorynoline is an alkaloid isolated from the tubers of Corydalis ambigua Cham. et Schltdl. It has anti-inflammatory properties with the potential to treat Parkinson’s disease.
Mengzhi Xu, Xicheng Dong, Yishun Fan, Yucan Wang, Jinmiao Xu, Jianshe Ma, Xiaomin Yu   +6 more
doaj   +1 more source

Effects of High Nitrogen Supply on the Susceptibility to Coolness at the Young Microspore Stage in Rice (Oryza sativa L.)

Plant Production Science, 2000
The combined effects of high nitrogen supply, cool temperature regimes and shading on factors related to fertility in rice plants were investigated. High nitrogen supply during the period from the spikelet differentiation stage to the young microspore ...
Takami Hayashi, Kazunari Kashiwabara, Tomoya Yamaguchi, Setsuo Koike   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Study of mouse behavior in different gravity environments

Scientific Reports, 2021
Many experiments have analyzed the effect of the space environment on various organisms. However, except for the group-rearing of mice in space, there has been little information on the behavior of organisms in response to gravity changes. In this study,
Michihiko Shimomura, Akane Yumoto, Naoko Ota-Murakami, Takashi Kudo, Masaki Shirakawa, Satoru Takahashi, Hironobu Morita, Dai Shiba   +7 more
doaj   +1 more source

Improved Performance of InGaZnO Thin-Film Transistor With Ti Incorporation Into La₂O₃ Gate Dielectric

IEEE Journal of the Electron Devices Society, 2021
The effects of Ti incorporation in La2O3 gate dielectric on the electrical characteristics of amorphous InGaZnO thin-film transistor are studied. Compared to the control sample with La2O3 gate dielectric, the device performance can be significantly ...
J. Q. Song, Y. Q. Yu, K. L. Zheng, Y. T. Su   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Effectiveness of Deer Repellents in Connecticut

Human-Wildlife Interactions, 2017
Browsing by overabundant herds of white-tailed deer (Odocoileus virginianus) can cause significant economic damage to agricultural crops and landscape plantings.
Jeffrey S. Ward, Scott C. Williams
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source