Results 31 to 40 of about 5,256,084 (284)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Determination and Pharmacokinetics of Acetylcorynoline in Mouse Plasma by UPLC–MS/MS
International Journal of Analytical ChemistryAcetylcorynoline is an alkaloid isolated from the tubers of Corydalis ambigua Cham. et Schltdl. It has anti-inflammatory properties with the potential to treat Parkinson’s disease.
Mengzhi Xu +6 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Plant Production Science, 2000 The combined effects of high nitrogen supply, cool temperature regimes and shading on factors related to fertility in rice plants were investigated. High nitrogen supply during the period from the spikelet differentiation stage to the young microspore ...
Takami Hayashi +3 more
doaj +1 more source
Study of mouse behavior in different gravity environments
Scientific Reports, 2021 Many experiments have analyzed the effect of the space environment on various organisms. However, except for the group-rearing of mice in space, there has been little information on the behavior of organisms in response to gravity changes. In this study,
Michihiko Shimomura +7 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Effectiveness of Deer Repellents in Connecticut
Human-Wildlife Interactions, 2017 Browsing by overabundant herds of white-tailed deer (Odocoileus virginianus) can cause significant economic damage to agricultural crops and landscape plantings.
Jeffrey S. Ward, Scott C. Williams
doaj +1 more source
Experimenting with a Design Experiment.
Revista internacional de sociologia, 2011 The design experiment is an experimental research method that aims to help design and further develop new (policy) instruments. For the development of a set of guidelines for the facilitation of citizens’ initiatives by local governments, we are experimenting with this method.
Bakker, Judith +1 more
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source