Results 41 to 50 of about 2,743,368 (242)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Epigallocatechin gallate attenuated high glucose-induced pancreatic beta cell dysfunction by modulating DRP1-mediated mitochondrial apoptosis pathways

Scientific Reports
Long-term exposure to hyperglycemic conditions leads to β-cell dysfunction, particularly mitochondrial dysfunction, and inflammatory and oxidative stress responses, which are considered the primary causes of β-cell death and the hallmarks of diabetes ...
Xu Jia, Danting Mao, Jianwei Guo, Jiangyu Ke, Yanlin Zhu, Xiaoyang Zhao, Ziren Luo, Xinghai Liu, Rui Tang, Ruihan Hou, Haitao Lan, Qian zheng   +11 more
doaj   +1 more source

Visual and fluorescent detection of Moraxella catarrhalis by multiple cross displacement amplification-based assay

Heliyon
Moraxella catarrhalis (M. catarrhalis), once considered as a harmless commensal bacterium, is now recognized as a significant pathogen associated with human mucosal infection.
Xiaolan Huang, Lei Yu, Chunrong Sun, Fei Xiao, Nan Jia, Min Chen, Yu Zhang, Jin Fu, Zheng Xu, Xiaodai Cui, Juan Zhou, Yi Wang   +11 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Study of mouse behavior in different gravity environments

Scientific Reports, 2021
Many experiments have analyzed the effect of the space environment on various organisms. However, except for the group-rearing of mice in space, there has been little information on the behavior of organisms in response to gravity changes. In this study,
Michihiko Shimomura, Akane Yumoto, Naoko Ota-Murakami, Takashi Kudo, Masaki Shirakawa, Satoru Takahashi, Hironobu Morita, Dai Shiba   +7 more
doaj   +1 more source

The Experiment Factory: Standardizing Behavioral Experiments [PDF]

Frontiers in Psychology, 2016
The administration of behavioral and experimental paradigms for psychology research is hindered by lack of a coordinated effort to develop and deploy standardized paradigms. While several frameworks (Mason and Suri, 2011; McDonnell et al., 2012; de Leeuw, 2015; Lange et al., 2015) have provided infrastructure and methods for individual research groups ...
Sochat, Vanessa V., Eisenberg, Ian W., Enkavi, A. Zeynep, Li, Jamie, Bissett, Patrick G., Poldrack, Russell A.   +5 more
openaire   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Determination of Rhenium in Copper-Lead-Zinc Ore by Inductively Coupled Plasma-Mass Spectrometry with Closed Decomposition and Cation Exchange Separation

Yankuang ceshi, 2015
Anion exchange resin has been applied to Re separation after acid digestion of Cu-Pb-Zn ores and Re was determined by Inductively Coupled Plasma-Mass Spectrometry(ICP-MS).
XIONG Ying, WU Zheng, DONG Ya-ni, PEI Ruo-hui, LIU Xiao-Yan, WU He, ZHANG Yan   +6 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source