Results 71 to 80 of about 24,496,433 (332)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiorgan morphological changes caused by hyperthermia: Case study on experimental model

Acta Marisiensis - Seria Medica, 2023
Morphologic changes in organs vary from nonspecific to specific ones, depending on causes of sudden death, e.i whether it is an acute, subacute or chronic event.
Dervišević Emina, Čamdžić Nina, Kuskunović-Vlahovljak Suada, Dervišević Muamer   +3 more
doaj   +1 more source

Experimental fully contextual correlations [PDF]

, 2012
Quantum correlations are contextual yet, in general, nothing prevents the existence of even more contextual correlations. We identify and test a noncontextuality inequality in which the quantum violation cannot be improved by any hypothetical postquantum
A. Peres, Adán Cabello, Antonio J. López-Tarrida, Elias Amselem, J. S. Bell, José R. Portillo, K. Svozil, Lars Eirik Danielsen, Mohamed Bourennane, S. Kochen   +9 more
core   +4 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Effect of an external vortex on the uav aerodynamic performances

EPJ Web of Conferences, 2012
In this present work, the CFD and wind tunnel are used to investigate the effect of an external vortex around an UAV in order to obtain initial estimates of lift and drag coefficients with flow velocity of 30 meters per second for various angles of ...
Imine Bachir, Yahiaoui Tayeb, Boudaoud Warda, Imine Omar   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Experimental test of magnetic photons

, 2004
A "magnetic" photon hypothesis associated with magnetic monopoles is tested experimentally. These photons are predicted to easily penetrate metal. Experimentally the optical transmittance T of a metal foil was less than 2 x 10^-17.
Barrow, Davies, Dirac, Fineberg, Goldhaber, Hagen, Ignatiev, Katz, Kühne, Lakes, Luo, Marques, Proca, R.S. Lakes, Salam, Taylor   +15 more
core   +1 more source

Experimental Satellite Quantum Communications [PDF]

, 2014
Quantum Communications on planetary scale require complementary channels including ground and satellite links. The former have progressed up to commercial stage using fiber-cables, while for satellite links, the absence of terminals in orbit has impaired
Bacco, Davide, Bianco, Giuseppe, Dequal, Daniele, Gaiarin, Simone, Luceri, Vincenza, Vallone, Giuseppe, Villoresi, Paolo   +6 more
core   +2 more sources