Results 21 to 30 of about 8,299,755 (321)
Chemotherapy of Experimental Leishmaniasis.
Experimental Biology and Medicine, 1946 SummaryA method for the routine evaluation of drugs for the therapy of visceral leishmaniasis in the hamster is described. No drug superior to Stibanose, Neostam or Neostibosan was discovered in tests of 27 other antimonials or of 158 additional metallic and non-metallic organic compounds.
Alfred Gellhorn, H. B. Van Dyke
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Magic bullets and moving targets: antibiotic resistance and experimental chemotherapy, 1900-1940.
Dynamis, 2011 It was in the 1940s that antibiotic resistance arose as an object of study for clinical medicine. Somewhat earlier it had become an important analytical tool for bacterial geneticists.
C. Gradmann
semanticscholar +1 more source
Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation
Scientific Reports, 2017 Podoplanin/Aggrus, known as a platelet aggregation-inducing factor, is frequently overexpressed in lung squamous cell carcinomas (LSCC) and glioblastomas among other tumours, and its expression has been reported to be correlated with poor prognosis ...
Kenichi Miyata +4 more
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Chemotherapy of Experimental Keratomycosis
American Journal of Ophthalmology, 1969 American Journal of Ophthalmology 68 (1969) 812-819. doi:10.1016/0002-9394(69)94573-5 ; Received by publisher: 0000-01-01 ; Harvest Date: 2016-01-04 12:19:01 ; DOI:10.1016/0002-9394(69)94573-5 ; Page Range: 812 ...
Department of Pharmacology and Therapeutics, Gainesville, Florida ( host institution ) +3 more
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Frontiers in Pharmacology, 2018 Chemotherapy is nowadays the main treatment of human cancers. Chemotherapeutic agents target rapidly dividing cancer cells to suppress tumor progression, however, their non-specific cytotoxicity often leads to significant side effects that might be ...
Bowen Fu +5 more
semanticscholar +1 more source
Nature Communications, 2019 The treatment of ROS1-rearranged non-small cell lung cancer with the TKI crizotinib is limited due to the emergence of resistance. Here, the authors develop a new ROS1/NTRK inhibitor, DS-6051b, which overcomes crizotinib resistance in preclinical models.
Ryohei Katayama +23 more
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Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay
eLife, 2021 In eukaryotes, histone variant distribution within the genome is the key epigenetic feature. To understand how each histone variant is targeted to the genome, we developed a new method, the RhIP (Reconstituted histone complex Incorporation into chromatin
Hiroaki Tachiwana +9 more
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Neoplasia: An International Journal for Oncology Research, 2013 Here, we show that forced expression of a B-cell lymphoma 2 (bcl-2) protein lacking residues 1 to 36 at the N-terminal, including the entire Bcl-2 homology 4 (BH4) domain, determines reduction of in vitro and in vivo human melanoma growth.
Daniela Trisciuoglio +8 more
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Urine based near-infrared spectroscopy analysis reveals a noninvasive and convenient diagnosis method for cancers: a pilot study [PDF]
PeerJ, 2023 Background The challenges in cancer diagnosis underline the need for continued research and development of new diagnostic tools and methods. This study aims to explore an effective, noninvasive, and convenient diagnostic tool using urine based near ...
Jing Zhu +6 more
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Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules
Biomedicines, 2022 Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Joni Vanneste +5 more
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