Results 11 to 20 of about 338,802 (261)
Chemotherapy of Experimental Leishmaniasis.
Experimental Biology and Medicine, 1946 SummaryA method for the routine evaluation of drugs for the therapy of visceral leishmaniasis in the hamster is described. No drug superior to Stibanose, Neostam or Neostibosan was discovered in tests of 27 other antimonials or of 158 additional metallic and non-metallic organic compounds.
H B, VAN DYKE, A, GELLHORN
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Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation
Scientific Reports, 2017 Podoplanin/Aggrus, known as a platelet aggregation-inducing factor, is frequently overexpressed in lung squamous cell carcinomas (LSCC) and glioblastomas among other tumours, and its expression has been reported to be correlated with poor prognosis ...
Kenichi Miyata +4 more
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Journal of Lipid Research, 1966 Simplified quantitative manipulations of very small amounts (30 μg) of lipids for determination of fatty acid content and composition by gas-liquid chromatography after (a) methanolysis (b) reduction and acetylation are described.
Francis M. Archibald +1 more
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Nature Communications, 2019 The treatment of ROS1-rearranged non-small cell lung cancer with the TKI crizotinib is limited due to the emergence of resistance. Here, the authors develop a new ROS1/NTRK inhibitor, DS-6051b, which overcomes crizotinib resistance in preclinical models.
Ryohei Katayama +23 more
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Neoplasia: An International Journal for Oncology Research, 2013 Here, we show that forced expression of a B-cell lymphoma 2 (bcl-2) protein lacking residues 1 to 36 at the N-terminal, including the entire Bcl-2 homology 4 (BH4) domain, determines reduction of in vitro and in vivo human melanoma growth.
Daniela Trisciuoglio +8 more
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Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay
eLife, 2021 In eukaryotes, histone variant distribution within the genome is the key epigenetic feature. To understand how each histone variant is targeted to the genome, we developed a new method, the RhIP (Reconstituted histone complex Incorporation into chromatin
Hiroaki Tachiwana +9 more
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Antimicrobial Agents and ChemotherapyPlasmodium falciparum, the deadliest causative agent of malaria, continues to evade eradication efforts through widespread drug resistance. The recent development of ADC-028, a 4-aminoquinoline antimalarial with excellent activity and pharmacokinetic ...
Mason J. Handford +5 more
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Journal of Lipid Research, 1971 Rats were given a single oral dose of cholestane-3β,5α,6β-triol-4-14C, and their feces were collected. The two major neutral metabolites were separated and isolated by use of solvent fractionation and chromatographic methods.
HENRY G. ROSCOE, MARVIN J. FAHRENBACH
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Separation of neutral glycosphingolipids and sulfatides by thin-layer chromatography
Journal of Lipid Research, 1967 Two one-dimensional systems for separation of glycolipids from total lipid extracts of tissues by thin-layer chromatography are described. System I used, as adsorbent, an alkaline mixture of silica gel without CaSO4 binder (75%) and magnesium silicate ...
Vladimir P. Skipski +2 more
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Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules
Biomedicines, 2022 Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Joni Vanneste +5 more
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