A comparison of general-purpose optimization algorithms forfinding optimal approximate experimental designs [PDF]
, 2019 Several common general purpose optimization algorithms are compared for findingA- and D-optimal designs for different types of statistical models of varying complexity,including high dimensional models with five and more factors.
Garcia-Garcia, Jose Carlos +4 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Optimized U-type Designs on Flexible Regions [PDF]
The concept of a flexible region describes an infinite variety of symmetrical shapes to enclose a particular region of interest within a space. In experimental design, the properties of a function on the region of interest is analyzed based on a set of ...
Chris Sharpe +2 more
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Experimental designs for environmental valuation with choice-experiments: A Monte Carlo investigation [PDF]
, 2005 We review the practice of experimental design in the environmental economics literature concerned with choice experiments. We then contrast this with advances in the field of experimental design and present a comparison of statistical efficiency across ...
Ferrini, Silvia, Scarpa, Riccardo
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
So you want to run an experiment, now what? Some Simple Rules of Thumb for Optimal Experimental Design [PDF]
Experimental economics represents a strong growth industry. In the past several decades the method has expanded beyond intellectual curiosity, now meriting consideration alongside the other more traditional empirical approaches used in economics ...
John A. List +2 more
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Large-bore tapered-roller bearing performance and endurance to 2.4 million DN [PDF]
, 1983 The operating characteristics and experimental life estimates for 120.65 mm bore tapered roller bearings of two designs under combined radial and thrust loads were determined. A modified standard bearing design was tested at speeds up to 15,000 rpm.
Parker, R. J.
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Response-Surface Methods in R, Using rsm
Journal of Statistical Software, 2009 This article describes the recent package rsm, which was designed to provide R support for standard response-surface methods. Functions are provided to generate central-composite and Box-Behnken designs.
Russell V. Lenth
doaj
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source