Results 121 to 130 of about 1,227,115 (260)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Defining and assessing immediacy in single-case experimental designs. [PDF]

J Exp Anal Behav, 2022
Manolov R, Onghena P.
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

DCATS: differential composition analysis for flexible single-cell experimental designs. [PDF]

Genome Biol, 2023
Lin X, Chau C, Ma K, Huang Y, Ho JWK.
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Competition and moral behavior: A meta-analysis of forty-five crowd-sourced experimental designs. [PDF]

Proc Natl Acad Sci U S A, 2023
Huber C, Dreber A, Huber J, Johannesson M, Kirchler M, Weitzel U, Abellán M, Adayeva X, Ay FC, Barron K, Berry Z, Bönte W, Brütt K, Bulutay M, Campos-Mercade P, Cardella E, Claassen MA, Cornelissen G, Dawson IGJ, Delnoij J, Demiral EE, Dimant E, Doerflinger JT, Dold M, Emery C, Fiala L, Fiedler S, Freddi E, Fries T, Gasiorowska A, Glogowsky U, M Gorny P, Gretton JD, Grohmann A, Hafenbrädl S, Handgraaf M, Hanoch Y, Hart E, Hennig M, Hudja S, Hütter M, Hyndman K, Ioannidis K, Isler O, Jeworrek S, Jolles D, Juanchich M, Kc RP, Khadjavi M, Kugler T, Li S, Lucas B, Mak V, Mechtel M, Merkle C, Meyers EA, Mollerstrom J, Nesterov A, Neyse L, Nieken P, Nussberger AM, Palumbo H, Peters K, Pirrone A, Qin X, Rahal RM, Rau H, Rincke J, Ronzani P, Roth Y, Saral AS, Schmitz J, Schneider F, Schram A, Schudy S, Schweitzer ME, Schwieren C, Scopelliti I, Sirota M, Sonnemans J, Soraperra I, Spantig L, Steimanis I, Steinmetz J, Suetens S, Theodoropoulou A, Urbig D, Vorlaufer T, Waibel J, Woods D, Yakobi O, Yilmaz O, Zaleskiewicz T, Zeisberger S, Holzmeister F.   +94 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Comparison between response surface methodology and Taguchi method for dyeing process parameters optimization in fabric manufacturing by empirical planning

Scientific Reports
This paper presents a comparative analysis of three experimental designs—Taguchi, Box–Behnken Design (BBD), and Central Composite Design (CCD)—for optimizing process parameters in a system with four factors at three levels. The study aims to identify the
D. Nikhila Sri, Rajyalakshmi Kottapalli, A. Pavani, Charankumar Ganteda, E. Gouthami, Assmaa Abd-Elmonem, Samah Abdelati Haroun, Syed M. Hussain, Mustafa Bayram, Abdulrazak H. Almaliki   +9 more
doaj   +1 more source

Bact-to-Batch: A Microbiota-Based Tool to Determine Optimal Animal Allocation in Experimental Designs. [PDF]

Int J Mol Sci, 2023
Even G, Mouray A, Vandenabeele N, Martel S, Merlin S, Lebrun-Ruer S, Chabé M, Audebert C.   +7 more
europepmc   +1 more source