Results 161 to 170 of about 1,227,115 (260)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Applying qualitative methods to experimental designs: A tutorial for the behavioral sciences. [PDF]

PLoS One
Leplaa HJ, Tönjes JA, Bouterse M, Soppe KFB, Klugkist I.   +4 more
europepmc   +1 more source

Theoretical and Experimental Designs on Several Mechanical Properties of Cu-Al-Zn Shape Memory Alloys Used in the Processing Industry. [PDF]

Materials (Basel), 2023
Plăcintă C, Stanciu S, Panainte-Lehadus M, Mosnegutu E, Nedeff F, Nedeff V, Tomozei C, Petrescu TC, Agop M.   +8 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Experimental designs used for optimising the effects of health interventions and implementation strategies: a scoping review. [PDF]

BMC Health Serv Res
Nolan E, Wolfenden L, Benn T, Holliday E, Barker D, Oldmeadow C, Hall A.   +6 more
europepmc   +1 more source

Optimizing an Enzymatic Extraction Method for the Flavonoids in Moringa (Moringa oleifera Lam.) Leaves Based on Experimental Designs Methodologies. [PDF]

Antioxidants (Basel), 2023
Polo-Castellano C, Mateos RM, Visiedo F, Palma M, Barbero GF, Ferreiro-González M.   +5 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Critical evaluation of factorial experimental designs and temporal confounding in comparative analysis of dietary vs parenteral iron administration effects on cortical and trabecular bone parameters. [PDF]

JBMR Plus
Zaheer MH, Shahnawaz Z, Zaheer H.
europepmc   +1 more source

Significant Differences and Experimental Designs Do Not Necessarily Imply Clinical Relevance: Effect Sizes and Causality Claims in Antidepressant Treatments. [PDF]

J Clin Med, 2023
Sánchez-Iglesias I, Martín-Aguilar C.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source