Results 171 to 180 of about 1,227,115 (260)

Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission. [PDF]

Genet Sel Evol, 2022
Pooley C, Marion G, Bishop S, Doeschl-Wilson A.   +3 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Optimizing experimental designs for model selection of ion channel drug-binding mechanisms. [PDF]

Philos Trans A Math Phys Eng Sci
Patten-Elliott F, Lei CL, Preston SP, Wilkinson RD, Mirams GR.   +4 more
europepmc   +1 more source

Single-case experimental designs for bumetanide across neurodevelopmental disorders: BUDDI protocol. [PDF]

BMC Psychiatry, 2022
Geertjens L, Cristian G, Haspels E, Ramautar J, van der Wilt GJ, Verhage M, Bruining H.   +6 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Automated discovery of experimental designs in super-resolution microscopy with XLuminA. [PDF]

Nat Commun
Rodríguez C, Arlt S, Möckl L, Krenn M.
europepmc   +1 more source

Primer of Epidemiology IV. Study designs II: Interventional or experimental designs. [PDF]

Natl Med J India, 2021
Singh K, Gupta P, Shivashankar R.
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Correspondence to the Letter to the Editor entitled "Critical evaluation of factorial experimental designs and temporal confounding in comparative analysis of dietary versus parenteral iron administration effects on cortical and trabecular bone parameters" by Zaheer M.H. et al. [PDF]

JBMR Plus
Spasić MV, Mayer B.
europepmc   +1 more source

Causal Mediation Analysis in Single Case Experimental Designs: Introduction to the Special Issue. [PDF]

Eval Health Prof, 2022
Miočević M, Moeyaert M, Mayer A, Montoya AK.   +3 more
europepmc   +1 more source