Results 51 to 60 of about 1,227,115 (260)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Mr.Bean: a comprehensive statistical and visualization application for modeling agricultural field trials data

Frontiers in Plant Science
Crop improvement efforts have exploited new methods for modeling spatial trends using the arrangement of the experimental units in the field. These methods have shown improvement in predicting the genetic potential of evaluated genotypes.
Johan Aparicio, Salvador A. Gezan, Daniel Ariza-Suarez, Bodo Raatz, Santiago Diaz, Ana Heilman-Morales, Juan Lobaton   +6 more
doaj   +1 more source

Optimization of Voltammetric Determination of Dysprosium (III) Using Plackett-Burman and RSM-CCD Experimental Designs

مجلة بغداد للعلوم, 2020
This study was aimed to develop an optimized Dy determination method using differential pulse voltammetry (DPV). The Plackett-Burman (PB) experimental design was used to select significant factors that affect the electrical current response, which were ...
Santhy Wyantuti, Zulida Setyorini, Safri Ishmayana, Yeni Hartati, M Firdaus   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Two polynomial representations of experimental design

, 2007
In the context of algebraic statistics an experimental design is described by a set of polynomials called the design ideal. This, in turn, is generated by finite sets of polynomials.
Notari, Roberto, Riccomagno, Eva, Rogantin, Maria-Piera   +2 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

An introduction to single-subject experimental designs

Interação em Psicologia, 2008
Os delineamentos de sujeito único constituem a abordagem experimental preferida por muitos pesquisadores do comportamento. Com o objetivo de introduzir o tema, discute-se o que é experimentação, definem-se variáveis independentes, dependentes e estranhas
Angelo Augusto Silva Sampaio, Flávia Henriques Baião de Azevedo, Luciana Roberta Donola Cardoso, Camila de Lima, Mateus Brasileiro Reis Pereira, Maria Amalia Pie Abib Andery   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

A tutorial on Quasi-experimental designs

Journal of Community Health Research, 2022
A main step in answering a scientific hypothesis in an epidemiological study is deciding which type of study is suitable to be undertaken, considering methodology, practical considerations and budget and time ...
Reyhane sefidkar, Farzan Madadizadeh
doaj